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N3376

Sigma-Aldrich

Nicotinamide

≥98% (HPLC), powder, PARP inhibitor

Synonyme(s) :

Acide nicotinique amide, Acide pyridine-3-carboxylique amide, Vitamine PP, Vitamine B3

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About This Item

Formule empirique (notation de Hill):
C6H6N2O
Numéro CAS:
98-92-0
Poids moléculaire :
122.12
Numéro Beilstein :
383619
Numéro CE :
202-713-4
Numéro MDL:
MFCD00006395
Code UNSPSC :
12352200
ID de substance PubChem :
24897638
Nomenclature NACRES :
NA.77

product name

Nicotinamide, ≥98% (HPLC), powder

Niveau de qualité

200

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white

Pf

128-131 °C (lit.)

Application(s)

cell analysis

Chaîne SMILES 

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

Clé InChI

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Informations sur le gène

human ... PARP1(142) , SIRT2(22933)

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Catégories apparentées

Application

Used as a cofactor for certain enzymes

Actions biochimiques/physiologiques

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Caractéristiques et avantages

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Stockage et stabilité

This product can be stored tightly closed in room temperature and in dry conditions.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319

Classification des risques

Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

302.0 °F - closed cup

Point d'éclair (°C)

150 °C - closed cup

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Christian W Johnson et al.
Cell reports, 28(6), 1538-1550 (2019-08-08)
Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas-driven colorectal cancers, while observed only rarely in HRas or
Salvatore Simmini et al.
Nature communications, 5, 5728-5728 (2014-12-17)
The endodermal lining of the adult gastro-intestinal tract harbours stem cells that are responsible for the day-to-day regeneration of the epithelium. Stem cells residing in the pyloric glands of the stomach and in the small intestinal crypts differ in their
Robert J Motzer et al.
The Lancet. Oncology, 14(6), 552-562 (2013-04-20)
In a phase 3 trial comparing the efficacy and safety of axitinib versus sorafenib as second-line treatment for metastatic renal cell carcinoma, patients given axitinib had a longer progression-free survival (PFS). Here, we report overall survival and updated efficacy, quality
Kathrin Schmeisser et al.
Nature chemical biology, 9(11), 693-700 (2013-10-01)
Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan. In contrast with recent observations, here we find that overexpression of sir-2.1, the ortholog of mammalian SirT1, does extend Caenorhabditis elegans lifespan. Sirtuins mandatorily convert NAD(+)
Thomas J Herzog et al.
Gynecologic oncology, 130(1), 25-30 (2013-04-18)
Sorafenib, an oral multikinase inhibitor of the VEGFR/PDGFR/Raf/MEK/ERK pathway, has shown potential activity in patients with recurrent ovarian cancer (OC). One strategy to prolong disease control and survival in patients with OC is maintenance therapy after achieving a complete response.
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