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47864

Supelco

Acide nicotinique

analytical standard

Synonyme(s) :

Acide 3-picolinique, Acide pyridine-3-carboxylique, Facteur de prévention de la pellagre

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About This Item

Formule empirique (notation de Hill) :
C6H5NO2
Numéro CAS:
59-67-6
Poids moléculaire :
123.11
Beilstein:
109591
Numéro CE :
200-441-0
Numéro MDL:
MFCD00006391
Code UNSPSC :
12164500
ID de substance PubChem :
24871534
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Qualité

analytical standard

CofA (certificat d'analyse)

current certificate can be downloaded

Caractéristiques

standard type water soluble vitamin

Conditionnement

ampule of 1000 mg

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Pf

236-239 °C (lit.)

Densité

1.473 g/cm3 at 25 °C

Application(s)

pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products

Format

neat

Température de stockage

2-30°C

Chaîne SMILES 

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

Clé InChI

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Informations sur le gène

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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Catégories apparentées

Description générale

Nicotinic acid acts as an antilipolytic drug in adipose tissue, and is commonly used for hyperlipoproteinaemia and pellagra.[1]
Nicotinic acid is a water soluble[2], vitamin belonging to B complex group of vitamins[3], which can be used as a broad spectrum lipid lowering drug.[4] Its mode of action basically involves the inhibition of the hormone-sensitive triglyceride lipase and thereby, decreasing the lipolysis in adipose tissue.[3][4]

Application

Nicotinic acid may be used as an analytical reference standard for the quantification of the analyte in tablet dosage forms using reversed-phase high-performance liquid chromatography technique.[1]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319

Classification des risques

Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

379.4 °F - closed cup

Point d'éclair (°C)

193 °C - closed cup

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
LRAD1574
LC25309V
LC23579V
LC21393V
LC18992V

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 2

1 of 2

Nicotinic acid for synthesis

Sigma-Aldrich

8.18714

Nicotinic acid

Acide nicotinique pour assurer la qualification des équipements European Pharmacopoeia (EP) Reference Standard

Y0001995

Acide nicotinique pour assurer la qualification des équipements

Nicotinic acid: the broad?spectrum lipid drug. A 50th anniversary review
Carlson.A.L
J. Int. Med., 258, 94-114 (2005)
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
Tunaru S, et al.
Nature Medicine, 9, 352-352 (2003)
Molecular identification of nicotinic acid receptor
Soga T, et al.
Biochemical and Biophysical Research Communications, 303, 364-369 (2003)
RP-HPLC method for the determination of atorvastatin calcium and nicotinic acid in combined tablet dosage form
Shah DA, et al.
Indian Journal of Pharmaceutical Sciences, 69(5), 700-700 (2007)
Koon K Teo et al.
Stroke, 44(10), 2688-2693 (2013-07-25)
In Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcomes (AIM-HIGH) trial, addition of extended-release niacin (ERN) to simvastatin in participants with established cardiovascular disease, low high-density lipoprotein cholesterol, and high triglycerides had no incremental
Afficher tous les articles scientifiques apparentés

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. questo standard è certificato iso17034 o iso 17025?

    1 answer

    1. Analytical standards are not ISO 17025 or 17034 certified. This level of certification is for a certified reference material such as product PHR1276.

      https://www.sigmaaldrich.com/product/sial/phr1276

      Helpful?

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