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Merck

59356-U

Supelco

Discovery® Cyano (5 µm) HPLC Columns

Discovery® Cyano HPLC Column

L × I.D. 15 cm × 4.6 mm, HPLC Column

Synonym(e):

Cyano-gebundene Phasensäule

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Produktbezeichnung

Discovery® Cyano HPLC-Säule, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

Materialien

stainless steel column

Qualitätsniveau

Agentur

suitable for USP L10

Produktlinie

Discovery®

Leistungsmerkmale

endcapped

Hersteller/Markenname

Discovery®

Verpackung

1 ea of

Kennzeichnungsgrad

4.5% Carbon loading

Parameter

≤70 °C temp. range
400 bar pressure (5801 psi)

Methode(n)

HPLC: suitable
LC/MS: suitable

L × ID

15 cm × 4.6 mm

Oberflächenbereich

200 m2/g

Oberflächendeckung

3.5 μmol/m2

Verunreinigungen

<10 ppm metals

Matrix

silica gel, high purity, spherical base material
fully porous particle

Aktive Matrixgruppe

cyano phase

Partikelgröße

5 μm

Porengröße

180 Å

pH Betriebsbereich

2-8

Anwendung(en)

food and beverages

Trenntechnik

hydrophilic interaction (HILIC)
normal phase
reversed phase

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Allgemeine Beschreibung

Die Discovery® Cyano HPLC-Säule wird für die Retention und Abscheidung von stark basischen Analyten, einschließlich quaternären Ammoniumsalzen, mit ausgezeichneten Peak-Formen verwendet.

Leistungsmerkmale und Vorteile

  • Geringe Hydrophobie für eine schnelle Elution von hydrophoben Analyten
  • Ausgezeichnete Peak-Form und Retention von stark basischen Analyten
  • Retention von polaren Analyten
  • Einzigartige Selektivität
  • Signifikant weniger Retention als C18 (erfordert in der Regel weniger % organischer mobiler Phase)
  • Stabile, gering blutende LC/MS-Trennungen
  • Kompatibel mit stark wässrigen organischen Phasen

Rechtliche Hinweise

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

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Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

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Kunden haben sich ebenfalls angesehen

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Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
Christophe Morisseau et al.
Analytical biochemistry, 414(1), 154-162 (2011-03-05)
The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics. In addition, it has a potential role in sexual development and bile acid transport, and it is associated with a number of diseases such as
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other

Questions

1–4 of 4 Questions  
  1. ¿Me podrías confirmar que la composición de esta columna es end-capped cyanosilyl silica gel for chromatography R? Gracias!

    1 answer
    1. These columns are end-capped, but the phase is cyanopropyl.

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  4. Please provide the below details for the column Carbon loading%- Pore size- Surface area- pH stability- End capping-

    1 answer
    1. TS Answer:
      - 4.5% Carbon loading
      - Pore size: 180 Å
      - Surface area: 200 m2/g
      - Operating pH range: 2-8
      - Endcapped
      - Particle Size: 5 μm
      - Temperature Range: ≤70 °C
      - Maximum Pressure: 400 bar pressure (5801 psi)
      - Suitable for USP L10

      Helpful?

Reviews

Active Filters

  1. India
    • Review 1
    • Votes 0
    2 out of 5 stars.

    Column to column variation

    Variation in Retention time from column to column observed

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for your review. While minor variability between batches may occur, the degree of difference in retention times would be impacted by run times. Assuming all other conditions are identical, an overall +/- 5% may be possible. As there are a number of variables to consider, we encourage customers who experience problems with our products to call or email us for additional technical support. Please visit https://www.sigmaaldrich.com/US/en/support/customer-support to submit a Product Technical Inquiry.

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