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577515-U

Supelco

Discovery® Cyano HPLC-Säule

5 μm particle size, L × I.D. 2 cm × 3 mm

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About This Item

UNSPSC-Code:
41115700
eCl@ss:
32110501

Materialien

stainless steel column

Agentur

suitable for USP L10

Produktlinie

Discovery®

Leistungsmerkmale

endcapped

Hersteller/Markenname

Discovery®

Verpackung

1 ea of

Kennzeichnungsgrad

4.5% Carbon loading

Parameter

≤70 °C temp. range
400 bar pressure (5801 psi)

Methode(n)

HPLC: suitable
LC/MS: suitable

L × ID

2 cm × 3 mm

Oberflächenbereich

200 m2/g

Oberflächendeckung

3.5 μmol/m2

Verunreinigungen

<10 ppm metals

Matrix

silica gel, high purity, spherical base material
fully porous particle

Aktive Matrixgruppe

cyano phase

Partikelgröße

5 μm

Porengröße

180 Å

operating pH range

2-8

Anwendung(en)

food and beverages

Trenntechnik

hydrophilic interaction (HILIC)
normal phase
reversed phase

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Leistungsmerkmale und Vorteile

  • Geringe Hydrophobie für eine schnelle Elution von hydrophoben Analyten
  • Ausgezeichnete Peak-Form und Retention von stark basischen Analyten
  • Retention von polaren Analyten
  • Einzigartige Selektivität
  • Signifikant weniger Retention als C18 (erfordert in der Regel weniger % organischer mobiler Phase)
  • Stabile, gering blutende LC/MS-Trennungen
  • Kompatibel mit stark wässrigen organischen Phasen

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Rechtliche Hinweise

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

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Analysenzertifikate (COA)

Lot/Batch Number

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Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
Christophe Morisseau et al.
Analytical biochemistry, 414(1), 154-162 (2011-03-05)
The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics. In addition, it has a potential role in sexual development and bile acid transport, and it is associated with a number of diseases such as
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other
E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
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Verwandter Inhalt

Discovery® HPLC Columns for Fast LC-MS Analysis

Discovery® HPLC Columns for Fast LC-MS Analysis. The Discovery LC-MS line offers short length columns for fast LC-MS analysis that are rugged and dependable. Supelco offers a robust product that withstands column shock due to fast gradient turnaround times.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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