T4827

Trandolapril

≥98% (HPLC), white, powder

• Synonym(e): (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid, Mavik
• Empirische Formel (Hill-System): C₂₄H₃₄N₂O₅
• CAS-Nummer: 87679-37-6
• Molekulargewicht: 430.54
• MDL-Nummer: MFCD00865776
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329826801
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: DMSO: ≥20 mg/mL
• Ersteller: Abbott
• SMILES String: CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2C3CCCCC3C[C@H]2C(O)=O
• InChI: 1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
• InChIKey: VXFJYXUZANRPDJ-WTNASJBWSA-N
• Angaben zum Gen: human ... ACE(1636)

Beschreibung

Anwendung

Trandolapril has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on responsiveness of human retinal endothelial cells (HRECs) to vascular endothelial growth factor (VEGF).[1]

Biochem./physiol. Wirkung

Studies have reported that trandolapril inhibits atherosclerosis¹ and decreases the occurrence of atrial fibrillation².

Trandolapril is an ACE inhibitor.

Trandolapril is an ACE inhibitor. Trandolapril differs from other ACE inhibitors in that it has a longer biological half-life and a high degree of lipophilicity.

Leistungsmerkmale und Vorteile

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Angaben zur Herstellung

Trandolapril is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H360D
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)