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Merck

T1516

Sigma-Aldrich

DL-Trihexyphenidyl -hydrochlorid

solid

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About This Item

Empirische Formel (Hill-System):
C20H31NO · HCl
CAS-Nummer:
Molekulargewicht:
337.93
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Form

solid

Farbe

white

Löslichkeit

methanol: soluble 50 mg/ml, clear to hazy, colorless
H2O: soluble

SMILES String

Cl[H].OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3

InChI

1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H

InChIKey

QDWJJTJNXAKQKD-UHFFFAOYSA-N

Anwendung

DL-Trihexyphenidyl hydrochloride has been used to develop a capillary zone electrophoretic method with end-column electrochemiluminescence (ECL)-based detection technique.

Biochem./physiol. Wirkung

DL-trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is known to function as an antimuscarinic agent and a centrally acting anticholinergic. It can be used for controlling the symptoms of all Parkinsonism types, such as the idiopathic, and postencephalitic arteriosclerotic forms. Benzhexol hydrochloride exerts inhibitory functions on the parasympathetic nervous system.
Muscarinic acetylcholine receptor antagonist

Angaben zur Herstellung

DL-Trihexyphenidyl hydrochloride is soluble in water. It dissolves in methanol at 50 mg/ml to yield a clear to hazy, colorless solution.

Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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T Hayakawa et al.
Clinical and experimental pharmacology & physiology, 26(5-6), 421-425 (1999-07-01)
1. Effects of anti-Parkinsonian drugs on neurobehavioural changes induced by bilateral lesions of dopaminergic neurons were investigated in rats. 2. Dopaminergic neurons in rats were lesioned bilaterally by injection of 6-hydroxydopamine (6-OHDA; 8 micrograms) into the medial forebrain bundle at
H E Shannon et al.
The Journal of pharmacology and experimental therapeutics, 290(2), 901-907 (1999-07-20)
The purpose of our studies was to determine the effects of muscarinic receptor agonists on conditioned avoidance responding in the rat. Rats were trained to avoid or escape an electric shock delivered to the feet in a discrete trial procedure.
Determination of benzhexol hydrochloride by capillary zone electrophoresis with an end-column electrochemiluminescence detection.
Yan, J., et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 76(1), 11-16 (2004)
Y Kimura et al.
Brain research, 834(1-2), 6-12 (1999-07-17)
An amnesic effect of anticholinergic drugs was previously described from several behavioral studies. We examined this effect induced by trihexyphenidyl and biperiden, clinically used in the parkinsonism and schizophrenic patients, by using passive avoidance tasks. Both of these drugs (0.1-10

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