SML2091

Dalcetrapib

≥97% (HPLC)

• Synonym(e): JTT-705, RO-4607381, S-[2-[[1-(2-ethylbutyl)cyclohexane]carbonylamino]phenyl]-2-methylpropanethioate
• Empirische Formel (Hill-System): C₂₃H₃₅NO₂S
• CAS-Nummer: 211513-37-0
• Molekulargewicht: 389.59
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD06407886
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CC(C)C(SC1=CC=CC=C1NC(C2(CCCCC2)CC(CC)CC)=O)=O
• InChI: 1S/C23H35NO2S/c1-5-18(6-2)16-23(14-10-7-11-15-23)22(26)24-19-12-8-9-13-20(19)27-21(25)17(3)4/h8-9,12-13,17-18H,5-7,10-11,14-16H2,1-4H3,(H,24,26)
• InChI key: YZQLWPMZQVHJED-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Cholesteryl ester transfer protein (CETP) inhibitor; increases serum levels of HDL-cholesterol

Dalcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor. It increases HDL levels, but showed variable results on clinical outcomes. Clinical outcomes, effects on C-reactive protein and cholesterol efflux have been found to be genotype-dependent, influenced by correlated polymorphisms in the ADCY9 (adenylate cyclase type 9) gene. Positive results were obtained with AA genotype of ADCY9 gene whereas the GG genotype showed negative results and the AG genotype was neutral.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable