SML1962

IWP-O1

≥98% (HPLC)

• Synonym(e): IWP-O1, 5-Phenyl-N-(5-phenylpyridin-2-yl)-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-acetamide, IWP-01
• Empirische Formel (Hill-System): C₂₆H₂₀N₆O
• CAS-Nummer: 2074607-48-8
• Molekulargewicht: 432.48
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 25 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: [n]3(nnc(c3c5ccccc5)c4ccncc4)CC(=O)Nc1ncc(cc1)c2ccccc2
• InChIKey: GYYDQHBKIHQHEB-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

IWP-O1 is an inhibitor of Porcupine (Porcn), an acyl (palmitoyl) transferase essential for secretion of Wnt proteins and involved in both embryonic development and tumor progression. IWP-O1 has good metabolic stability and is extremely potent, exhibiting an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling.

Porcn Inhibitor

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable