SML1940

ADDA 5 hydrochloride

≥98% (HPLC)

• Synonym(e): 1-[2-(1-Adamantyl)ethoxy]-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-propanol hydrochloride, 3,4-Dihydro-α-[(2-tricyclo[3.3.1.13,7]dec-1-ylethoxy)methyl]-2(1H)-isoquinolineethanol hydrochloride
• Empirische Formel (Hill-System): C₂₄H₃₅NO₂ · HCl
• CAS-Nummer: 473268-46-1
• Molekulargewicht: 406.00
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: OC(CN1CCC(C=CC=C2)=C2C1)COCCC34C[C@H]5C[C@H](C[C@H](C5)C4)C3.[H]Cl

Beschreibung

Anwendung

ADDA 5 hydrochloride has been used as a complex IV inhibitor to study its effects on leptomeningeal derivatives of human breast and lung cancer cells.[1]

Biochem./physiol. Wirkung

ADDA 5 is a potent and selective inhibitor of cytochrome c oxidase (Complex IV) that depletes the bioenergetics reserve capacity in intact glioma cells. ADDA 5 specifically inhibits the proliferation of chemosensitive and chemoresistant glioma cells, while sparing non-cancer cells. Additionally ADDA 5 is effective against glioma stem cells.

Potent and selective inhibitor of cytochrome c oxidase (Complex IV)

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable