This product is an oil, the solubility has not been tested. However, It is reportedly soluble in DMSO, acetonitrile, acetone, chloroform , dichloromethane. Avoid methanol and ethanol as this will cause the product to quickly degrade. For HPLC applications, DMSO is the preferred solvent. Please see the link below to review a publication that may be helpful:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484159/
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SML1743
ETaKG
≥95% (HPLC)
Synonym(e):
2-Oxo-pentanedioic acid 5-ethyl ester 1-(3-trifluoromethyl-benzyl) ester, 5-Ethyl 1-(3-(trifluoromethyl)benzyl) 2-oxopentanedioate
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5 MG
CHF 109.00
25 MG
CHF 443.00
CHF 109.00
Voraussichtliches Versanddatum22. Mai 2025
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5 MG
CHF 109.00
25 MG
CHF 443.00
About This Item
Empirische Formel (Hill-System):
C15H15F3O5
CAS-Nummer:
Molekulargewicht:
332.27
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
CHF 109.00
Voraussichtliches Versanddatum22. Mai 2025
Empfohlene Produkte
Qualitätsniveau
Assay
≥95% (HPLC)
Form
oil
Farbe
colorless to light yellow
Lagertemp.
2-8°C
SMILES String
O=C(C(CCC(OCC)=O)=O)OCC1=CC=CC(C(F)(F)F)=C1
InChI
1S/C15H15F3O5/c1-2-22-13(20)7-6-12(19)14(21)23-9-10-4-3-5-11(8-10)15(16,17)18/h3-5,8H,2,6-7,9H2,1H3
InChIKey
OKDCLZOKKGLMIX-UHFFFAOYSA-N
Biochem./physiol. Wirkung
A cell-permeable, bioavailable & aqueous stable α-ketoglutarate prodrug that selectively induces PHD-dependent cell death in hypoxic cells
ETaKG is a cell-permeable, aqueous stable, bioavailable, non-toxic α-ketoglutarate/2-oxoglutarate (α-KG/2-OG) diester derivative that readily undergoes hydrolysis by cytosolic esterases to α-KG. The monoester analog, TaKG is also membrane permeant. ETaKG elevates intracellular [α-KG] by ~15-fold in a prologned fashion, destabilizes HIF-1α/2α and reactivates prolyl hydroxylases (PHDs) in hypoxic HCT116, A431 and RPE cells at 2 mM. Further, shown to selectively trigger PHD-dependent cell death in hypoxic cells and decreases cellular [ATP] and glucose uptake. ETaKG has shown to reduce glucose metabolism, elevate [α-KG] levels and suppress A375 xenograft tumor growth (750 mg/kg of mice, p.o., q.d., 14 days). Also, induces mTORC1 lysosomal translocation and stimulates mTORC1 activity in the absence of glutaminolysis in U2OS cells.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Hanumantha Rao Madala et al.
Cancer research, 80(17), 3492-3506 (2020-07-12)
Under conditions of inherent or induced mitochondrial dysfunction, cancer cells manifest overlapping metabolic phenotypes, suggesting that they may be targeted via a common approach. Here, we use multiple oxidative phosphorylation (OXPHOS)-competent and incompetent cancer cell pairs to demonstrate that treatment
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Hi Can you please tell me about the solubility and the concentration of EtaKG ? DMSO ? Best regards Salwan
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