SML0889

bpV(phen)

≥95% V basis

• Synonym(e): Potassium bisperoxo(1,10-phenanthroline)oxovanadate (V) hydrate
• Empirische Formel (Hill-System): KVO₅C₁₂H₈N₂ · xH₂O
• CAS-Nummer: 42494-73-5
• Molekulargewicht: 350.24 (anhydrous basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% V basis
• Form: powder
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥95% V basis
• form: powder
• storage condition: protect from light
• color: faintly yellow to dark yellow
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=[V]123([N]4=CC=CC5=C4C6=C(C=CC=[N]62)C=C5)(OO3)OO1.[K]
• InChI: 1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;/h1-8H;;2*1-2H;;/q;+1;;;;
• InChI key: MQPXOTNOFVCXDA-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC₅₀ values for bpV(phen) are 38 nM for PTEN compared to 343 nM for PTPβ and 920 nM for PTP-1β. bpV(phen) has anti-inflammatory effects in oxidative stress including inhibitory effects on oxidative stress-induced cardiomyocyte injury that may be partially modulated by the action of ROS on PTEN. It may also be involved in differentiation.

bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.

bpV(phen) (potassium bisperoxo(bipyridine)oxovanadate) shows protective effect against disease progression in leishmaniasis by mediating NO-dependent microbicidal action.

Other Notes

Light Sensitive

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable