SML0653

Capecitabin

≥98% (HPLC)

• Synonym(e): 5′-Deoxy-5-fluor-N-[(pentyloxy)-carbonyl]-cytidin, Ro-9-1978
• Empirische Formel (Hill-System): C₁₅H₂₂FN₃O₆
• CAS-Nummer: 154361-50-9
• Molekulargewicht: 359.35
• MDL-Nummer: MFCD00930626
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825576
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +80 to +100°, c = 0.5 in methanol
• Farbe: white to beige
• Löslichkeit: H₂O: 10 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: O[C@H]1[C@@H](O)[C@H](N2C(N=C(NC(OCCCCC)=O)C(F)=C2)=O)O[C@@H]1C
• InChI: 1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1
• InChIKey: GAGWJHPBXLXJQN-UORFTKCHSA-N
• Angaben zum Gen: human ... TYMS(7298)

Beschreibung

Anwendung

Capecitabine has been used:

• in combination with gemcitabine to achieve glutamine deprivation by enhancing the sensitivity of expression in pancreatic ductal adenocarcinoma (PDAC) cells to inhibitors of glutamine metabolism and study its effect on PDAC cell survival[1]
• to study the drug metabolic function in a two-organ microfluidic system[2]
• as an anti-cancer agent to study its cytotoxic activity alone or in combination with B87 on cancer cells[3]

Biochem./physiol. Wirkung

Capecitabine is an anti-cancer drug, a prodrug of doxifluridine, metabolized to 5-fluorouracil at the tumor site.

Capecitabine is an anti-cancer drug, a prodrug of doxifluridine, metabolized to 5-fluorouracil at the tumor site. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5′-Deoxy-5-fluorocytidine (5′-DFCR) and 5′-Deoxy-5-fluorouridine (5′-DFUR), to form 5-fluorouracil.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H341,H350,H360FD
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Carc. 1B - Muta. 2 - Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable