SMB00286

Terconazol

≥98%

• Synonym(e): (+-)-1-{4-[cis-2-(2,4-Dichlorphenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]-phenyl}-4-isopropylpiperazin, Triaconazol
• Empirische Formel (Hill-System): C₂₆H₃₁Cl₂N₅O₃
• CAS-Nummer: 67915-31-5
• Molekulargewicht: 532.46
• EG-Nummer: 267-751-6
• UNSPSC-Code: 51101500
• NACRES: NA.85

Eigenschaften

• Assay: ≥98%
• Form: powder
• Farbe: white
• Löslichkeit: DMSO: 1 mg/mL
• Wirkungsspektrum von Antibiotika: fungi
• Wirkungsweise: enzyme | interferes
• Lagertemp.: 2-8°C
• InChI: 1S/C26H31Cl2N5O3/c1-19(2)31-9-11-32(12-10-31)21-4-6-22(7-5-21)34-14-23-15-35-26(36-23,16-33-18-29-17-30-33)24-8-3-20(27)13-25(24)28/h3-8,13,17-19,23H,9-12,14-16H2,1-2H3/t23-,26-/m0/s1
• InChIKey: BLSQLHNBWJLIBQ-OZXSUGGESA-N

Beschreibung

Allgemeine Beschreibung

Terconazole is a traizole ketal derivative, which is antifungal in nature. It is especially effective against Candidal spp.

Anwendung

Terconazole could be used for the assessment of the effect of terconazole on transduction efficiency of host cells by glycoprotein of Ebola virus (EBOV), and for the assessment of the effect of terconazole on transduction efficiency of embryonic kidney cell line 293T by human coronaviruses.

Biochem./physiol. Wirkung

Terconazole suppresses the growth of various types of yeats and mycelium-forming fungi in in vitro conditions. Its antifungal activity is an outcome of the accumulation of the membrane-disrupting 14α-demethylsterols and ergosterol depletion. This is result of inactivation of cytochrome P-450-dependent 14α-demethylase by terconazole. It is a rapidly-acting and well-tolerated antifungal used for the treatment of vulvovaginal candidiasis. It is also used for the treatment of dermatophytosis and candidosis. The drug may facilitate the accumulation of cholesterol in late endosomes.

Verpackung

2MG

Lagerung und Haltbarkeit

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non Combustible Solids

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335,H413
• P-Sätze: P273 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable