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S4069

Sigma-Aldrich

SL327

≥98% (HPLC), Mixture of E & Z isomers, solid

Synonym(e):

α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile, SL 327, SL-327

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About This Item

Empirische Formel (Hill-System):
C16H12F3N3S
CAS-Nummer:
305350-87-2
Molekulargewicht:
335.35
MDL-Nummer:
MFCD06411432
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329824537
NACRES:
NA.77

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Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

desiccated
protect from light

Farbe

white to off-white

mp (Schmelzpunkt)

127-128.2 °C

Löslichkeit

DMSO: >10 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F

InChI

1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+

InChIKey

JLOXTZFYJNCPIS-FYWRMAATSA-N

Anwendung

SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos[1] and lymphatic endothelial cell (LEC).[2]
SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats.[3] It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.[4]

Biochem./physiol. Wirkung

SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro.
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000141784
0000071402
0000034691
0000034692
0000026839

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Die Dokumentenbibliothek aufrufen

Stephanie M Fernandez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(35), 8660-8667 (2008-08-30)
The extracellular signal-regulated kinase (ERK) pathway is critical for various forms of learning and memory, and is activated by the potent estrogen 17beta-estradiol (E(2)). Here, we asked whether E(2) modulates memory via ERK activation and putative membrane-bound estrogen receptors (ERs).
Gisela Borges et al.
The international journal of neuropsychopharmacology, 20(6), 463-463 (2017-02-06)
There is increasing evidence suggesting that the Locus Coeruleus plays a role in pain-related anxiety. Indeed, we previously found that prolonged arthritis produces anxiety-like behavior in rats, along with enhanced expression of phosphorylated extracellular signal-regulated kinase 1/2 (a marker of
Daniel T Barkmeier et al.
Neurobiology of disease, 47(1), 92-101 (2012-04-05)
Epilepsy is a disease characterized by chronic seizures, but is associated with significant comorbidities between seizures including cognitive impairments, hyperactivity, and depression. To study this interictal state, we characterized the electrical, molecular, and behavior effects of chronic, neocortical interictal spiking
Lin Grimm et al.
eLife, 8 (2019-05-01)
Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, proliferation and tissue growth to form a complex second vasculature. The Hippo pathway and effectors Yap and Taz control organ growth and regulate morphogenesis and cellular proliferation.
Daniel A Lee et al.
Science advances, 5(11), eaax4249-eaax4249 (2019-11-26)
The genetic bases for most human sleep disorders and for variation in human sleep quantity and quality are largely unknown. Using the zebrafish, a diurnal vertebrate, to investigate the genetic regulation of sleep, we found that epidermal growth factor receptor
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