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Dokumente

R0658

Sigma-Aldrich

RN-1734

≥98% (HPLC)

Synonym(e):

2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide

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About This Item

Empirische Formel (Hill-System):
C14H22Cl2N2O2S
CAS-Nummer:
946387-07-1
Molekulargewicht:
353.31
MDL-Nummer:
MFCD00129453
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329823990
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to off-white

Löslichkeit

DMSO: >20 mg/mL

Lagertemp.

2-8°C

SMILES String

ClC1=C(S(N(C(C)C)CCNC(C)C)(=O)=O)C=CC(Cl)=C1

InChI

1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3

InChIKey

IHYZMEAZAIFMTN-UHFFFAOYSA-N

Anwendung

RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.

Biochem./physiol. Wirkung

RN-1734 is a selective TRPV4 antagonist.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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SKF-96365 ≥98% (HPLC), solid

Sigma-Aldrich

S7809

SKF-96365

Rutheniumrot Technical grade

Sigma-Aldrich

R2751

Rutheniumrot

Agarose, niedrige Geliertemperatur BioReagent, for molecular biology

Sigma-Aldrich

A9414

Agarose, niedrige Geliertemperatur

TRPV4 regulates tight junctions and affects differentiation in a cell culture model of the corneal epithelium
Martinez R, et al.
Journal of Cellular Physiology, 232(7), 1794-1807 (2017)
Jacqueline Martínez-Rendón et al.
Journal of cellular physiology, 232(7), 1794-1807 (2016-11-22)
TRPV4 (transient receptor potential vanilloid 4) is a cation channel activated by hypotonicity, moderate heat, or shear stress. We describe the expression of TRPV4 during the differentiation of a corneal epithelial cell model, RCE1(5T5) cells. TRPV4 is a late differentiation
Vittorio Abbonante et al.
Haematologica, 102(7), 1150-1160 (2017-04-16)
Megakaryocytes (MK) in the bone marrow (BM) are immersed in a network of extracellular matrix components that regulates platelet release into the circulation. Combining biological and bioengineering approaches, we found that the activation of transient receptor potential cation channel subfamily
Hemant Kumar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(9), 1943-1955 (2020-01-25)
Currently, the role of transient receptor potential vanilloid type 4 (TRPV4), a nonselective cation channel in the pathology of spinal cord injury (SCI), is not recognized. Herein, we report the expression and contribution of TRPV4 in the pathology of scarring
Silvia Ghirga et al.
Journal of the Optical Society of America. A, Optics, image science, and vision, 37(4), 643-652 (2020-05-14)
It has been recently demonstrated that the exposure of naive neuronal cells to light-at the basis of optogenetic techniques and calcium imaging measurements-may alter neuronal firing. Indeed, understanding the effect of light on nongenetically modified neurons is crucial for a
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