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P8157

Sigma-Aldrich

Phallacidin from Amanita phalloides

≥85%

Synonym(e):

Cyclo(Ala-2-Mercapto-Trp-4,5-Dihydroxy-Leu-Val-erythro-3-Hydroxy-D-Asp-Cys-cis-4-Hydroxy-Pro)

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About This Item

Empirische Formel (Hill-System):
C37H50N8O13S
CAS-Nummer:
26645-35-2
Molekulargewicht:
846.90
MDL-Nummer:
MFCD00063359
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24898913
NACRES:
NA.56

Biologische Quelle

Amanita phalloides

Assay

≥85%

Form

powder

SMILES String

CC(C)C1NC(=O)C(CC(C)(O)CO)NC(=O)C2Cc3c(SCC(NC(=O)C(NC1=O)C(O)C(O)=O)C(=O)N4CC(O)CC4C(=O)NC(C)C(=O)N2)[nH]c5ccccc35

InChI

1S/C37H50N8O13S/c1-15(2)25-32(53)44-26(27(48)36(56)57)33(54)41-23-13-59-34-19(18-7-5-6-8-20(18)42-34)10-21(29(50)40-22(30(51)43-25)11-37(4,58)14-46)39-28(49)16(3)38-31(52)24-9-17(47)12-45(24)35(23)55/h5-8,15-17,21-27,42,46-48,58H,9-14H2,1-4H3,(H,38,52)(H,39,49)(H,40,50)(H,41,54)(H,43,51)(H,44,53)(H,56,57)

InChIKey

KUBDTFZQCYLLGC-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Phallacidin, which is a bicyclic toxin from the Amanita phalloides mushroom, has been shown to inhibit F-actin degradation by proteolytic enzymes including trypsin and α-chymotrypsin.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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International archives of allergy and immunology, 110(4), 325-331 (1996-08-01)
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The American journal of physiology, 276(1 Pt 1), L20-L27 (1999-01-14)
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P Hofman et al.
The American journal of physiology, 271(1 Pt 1), C312-C320 (1996-07-01)
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