P6628

Pilocarpin -nitrat (Salz)

≥98% (HPLC)

• Empirische Formel (Hill-System): C₁₁H₁₆N₂O₂ · HNO₃
• CAS-Nummer: 148-72-1
• Molekulargewicht: 271.27
• Beilstein: 4171406
• EG-Nummer: 205-723-7
• MDL-Nummer: MFCD00078497
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 57654548
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]25/D +83°, c = 10 in H₂O(lit.)
• Farbe: white
• Löslichkeit: H₂O: 100 mg/mL
• SMILES String: O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
• InChI: 1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
• InChIKey: PRZXEPJJHQYOGF-GNAZCLTHSA-N
• Angaben zum Gen: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

Beschreibung

Anwendung

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

Biochem./physiol. Wirkung

Nicht-selektiver muskarinischer Acetylcholin-Rezeptoragonist, verwendet für ein experimentelles Epilepsiemodell.

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Sicherheitshinweise

• Piktogramme: GHS03,GHS06
• Signalwort: Danger
• H-Sätze: H272,H302,H330
• P-Sätze: P210 - P220 - P260 - P264 - P301 + P312 - P304 + P340 + P310
• Gefahreneinstufungen: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2
• Lagerklassenschlüssel: 5.1B - Oxidizing hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges