Phosphatidylserine is important in enzymatic assays of purified protein kinase C. During activation of this enzyme, as part of the signal transduction process, phosphatidylserine, which is located on the inside of cellular plasma membranes, binds to cysteine residue domains on protein kinase C. Phosphatidylserine can be used as a standard in thin-layer chromatography and for artificial membrane studies such as in lipsome research.
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P5660
3-sn-Phosphatidyl-L-serin Natriumsalz aus Rinderhirn
≥95% (TLC)
Synonym(e):
1,2-Diacyl-sn-glycero-3-phospho-L-serine, L-α-Phosphatidyl-L-serine sodium salt
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Größe auswählen
5 MG
CHF 377.00
25 MG
CHF 1’500.00
100 MG
CHF 4’020.00
Alle Fotos(2)
Größe auswählen
Ansicht ändern
5 MG
CHF 377.00
25 MG
CHF 1’500.00
100 MG
CHF 4’020.00
About This Item
Empfohlene Produkte
Assay
≥95% (TLC)
Form
powder
Lagertemp.
−20°C
SMILES String
[Na+].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C([O-])=O)OC(=O)CCCCCCCCCCCCCCCCC
InChI
1S/C42H82NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49);/q;+1/p-1/t38-,39+;/m1./s1
InChIKey
SJRBMGBLPUBGJL-MBAWARMDSA-M
Allgemeine Beschreibung
Anwendung
3-sn-Phosphatidyl-L-serine sodium salt from bovine brain has been used as a glycosylphosphatidylinositol (GPI)-anchor control.[3]
Biochem./physiol. Wirkung
A slowly metabolized structural phospholipid found mainly in gray matter.
Vorsicht
Solutions exposed to room temperature will decompose about 0.5% per day.
Angaben zur Herstellung
Washed with EDTA and converted to a sodium salt.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Analysenzertifikate (COA)
Lot/Batch Number
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Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression
Fadeel B, et al.
Biochemical and Biophysical Research Communications, 266(2), 504-511 (1999)
The role of phosphatidylserine in recognition and removal of erythrocytes.
Kuypers FD
Cellular and molecular biology (Noisy-le-Grand, France), 50(2), 147-158 (2004)
TIMP-1-GPI in combination with hyperthermic treatment of melanoma increases sensitivity to FAS-mediated apoptosis
Djafarzadeh R, et al.
Cancer Immunology, Immunotherapy, 58(3), 361-361 (2009)
Exposure of platelet membrane phosphatidylserine regulates blood coagulation
Lentz BR
Progress in Lipid Research, 42(5), 423-438 (2003)
Julien Perino et al.
Antiviral research, 89(1), 89-97 (2010-11-26)
Vaccinia virus (VACV) was used as a surrogate of Variola virus (genus Orthopoxvirus), the causative agent of smallpox, to study orthopoxvirus infection via the respiratory airway. Lung surfactant, a physiological barrier to infection encountered by the virus, is predominantly composed
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What is Product P5660, 3-sn-Phosphatidyl-L-serine sodium salt, commonly used for?
1 answer-
Helpful?
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Is 3-sn-Phosphatidyl-L-serine sodium salt from bovine brain available in solution?
1 answer-
Yes. Product No. P6641 is a ready-to-use solution of phosphatidylserine in a chloroform:methanol mixture.
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Do you have any inhibitors for Protein Kinase C (PKC)?
1 answer-
Yes. Two examples are Product No. C6303 (Calphostin C from Cladosporium cladosporioides) and Product No. C2932 (Chelerythrine chloride).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the molecular weight of Product P5660, 3-sn-Phosphatidyl-L-serine sodium salt from bovine brain?
1 answer-
The molecular weight of this compound is approximately 812.1 g/mole. This molecular weight assumes that stearoyl and oleoyl are the prodimant fatty acids in the compound. Phosphatidylserine may have a number of different fatty acid residues associated with it. Our analyses of multiple lots of phosphatidylserine identified average fatty acid percentages of approximately 40% for stearic acid and 30% for oleic acid.
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What is Product P5660, 3-sn-Phosphatidyl-L-serine sodium salt from bovine brain, soluble in?
1 answer-
This product is soluble in chloroform:methanol (95:5 v/v) at a concentration of 50 mg/mL. It will likely form a suspension or emulsion in deionized water at a concentration of 1 mg/mL or higher.
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What is the solution stability of Product P5660, 3-sn-Phosphatidyl-L-serine sodium salt from bovine brain?
1 answer-
Solutions can be divided into aliquots and stored at -20 °C. We have no information as to how long the solutions will be stable. Solution stability is enhanced when the compound is protected from oxygen, because the unsaturated fatty acids are subject to oxidation. To protect from oxidation, dissolve the compound in solvents in which oxygen has been removed and replaced with an inert gas such as nitrogen or argon.
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