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Merck

P3513

Sigma-Aldrich

Poly-L-lysine, succinylated

mol wt >50,000

Synonym(e):

Modified Lysine Copolymer

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352209
NACRES:
NA.26

Form

powder or solid

Mol-Gew.

>50,000

Farbe

white to faint yellow

Anwendung(en)

cell analysis

Lagertemp.

−20°C

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Anwendung

Succinylated poly-L-lysine has been used to bind (Gly)3-Arg-bradykinin to study its hydrolysis by brain endopeptidases and pancreatic proteinases.

Biochem./physiol. Wirkung

Poly-L-lysine is a cationic polymer. It is mainly used for immobilizing cells to glass substrates or negatively charged substrates.
An intermediate for coupling proteins to poly-L-lysine.

Hinweis zur Analyse

Molecular weight based on precursor poly-L-lysine viscosity. Also assayed by MALLS.

Sonstige Hinweise

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Effects of poly(L-lysine) substrates on attached Escherichia coli bacteria.
Colville K
Langmuir, 26(4), 2639-2644 (2010)
Sofia Helena Linnea Frost et al.
Cancer biotherapy & radiopharmaceuticals, 26(6), 727-736 (2011-11-18)
Avidin-coupled monoclonal antibody MX35 (avidin-MX35) and astatine-211-labeled, biotinylated, succinylated poly-l-lysine ((211)At-B-PL(suc)) were administered in mice to assess potential efficacy as an intraperitoneal (i.p.) therapy for microscopic tumors. We aimed to establish a timeline for pretargeted radioimmunotherapy using these substances, and
Susceptibility of a Peptide Derived from Bradykinin to Hydrolysis by Brain Endo-oligopeptidases and Pancreatic Proteinases*
Antonio C. M. Camargo
The Journal of Biological Chemistry, 254(12), 5304-5307 (1979)
M R Hamblin et al.
British journal of cancer, 89(5), 937-943 (2003-08-28)
Conjugates between photosensitisers (PS) and charged polymeric carriers are under investigation for photodynamic therapy of cancer and may allow targeting to certain cell types or compartments in tumours. Covalent attachment of polyethylene glycol to macromolecules (pegylation) may alter their pharmacokinetics
V S Trubetskoy et al.
Nucleic acids research, 27(15), 3090-3095 (1999-08-24)
DNA can be condensed with an excess of poly-cations in aqueous solutions forming stable particles of submicron size with positive surface charge. This charge surplus can be used to deposit alternating layers of polyanions and polycations on the surface surrounding

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