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Merck

N8757

Sigma-Aldrich

Neohesperidin-Dihydrochalkon

≥95% (HPLC)

Synonym(e):

1-(4-((2-O-[6-Deoxy-α-L-mannopyranosyl]-β-D-glucopyranosyl)-oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanon, NHDC

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About This Item

Empirische Formel (Hill-System):
C28H36O15
CAS-Nummer:
Molekulargewicht:
612.58
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352201
PubChem Substanz-ID:
NACRES:
NA.25

Assay

≥95% (HPLC)

Form

powder

Süße

1500 × sucrose

Verunreinigungen

<12% water

Farbe

white to off-white

mp (Schmelzpunkt)

156-158 °C (lit.)

Löslichkeit

water: 50 mg/mL, clear, yellow

Lagertemp.

−20°C

SMILES String

COc1ccc(CCC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)cc2O)cc1O

InChI

1S/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1

InChIKey

ITVGXXMINPYUHD-CUVHLRMHSA-N

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Allgemeine Beschreibung

Neohesperidin dihydrochalcone is an artificial sweetener.

Anwendung

Neohesperidin dihydrochalcone has been used in a study to assess levels of nine high-intensity sweeteners in various foods. It can be used as a therapeutic agent on reactive oxygen species-related inflammatory disease.

Biochem./physiol. Wirkung

Flavonoid sweetening agent with potent antioxidant activity.

Sonstige Hinweise

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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R K Sahu et al.
Mutation research, 89(1), 69-74 (1981-05-01)
4 important flavonoid compounds, namely quercetin, kaempferol, neohesperidin dihydrochalcone and rutin, were administered to male mice for the detection of gross chromosomal anomalies by the micronucleus test. The first 3 compounds were positively clastogenic to different extents, whereas the 4th
J H Kroeze
Chemical senses, 25(5), 555-559 (2000-10-04)
Neohesperidin dihydrochalcone (NHDC) is an intensive sweetener, obtained by alkaline hydrogenation of neohesperidin. In this investigation a supposed taste enhancing effect of this substance was tested. A three-step procedure was used. In the first experiment, using a pool of 31
Agata Zygler et al.
Analytical and bioanalytical chemistry, 400(7), 2159-2172 (2011-04-06)
An analytical procedure involving solid-phase extraction (SPE) and high-performance liquid chromatography-mass spectrometry has been developed for the determination of nine high-intensity sweeteners authorised in the EU; acesulfame-K (ACS-K), aspartame (ASP), alitame (ALI), cyclamate (CYC), dulcin (DUL), neohesperidin dihydrochalcone (NHDC), neotame
Marcel Winnig et al.
BMC structural biology, 7, 66-66 (2007-10-16)
Differences in sweet taste perception among species depend on structural variations of the sweet taste receptor. The commercially used isovanillyl sweetener neohesperidin dihydrochalcone activates the human but not the rat sweet receptor TAS1R2+TAS1R3. Analysis of interspecies combinations and chimeras of
A Ly et al.
Chemical senses, 26(1), 41-47 (2000-12-22)
The genetically determined ability to taste 6-n-propylthiouracil (PROP) has been linked with lowered acceptance of some bitter foods. Fifty-four women, aged 18-30 years, tasted and rated PROP-impregnated filter paper and seven solutions of PROP. Summed bitterness intensity ratings for PROP

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