L5413

Formyl-[D-Trp⁶]-LH-RH Fragment 2-10

>97% (HPLC)

• Synonym(e): Formyl-Triptorelin 2-10
• Empirische Formel (Hill-System): C₆₀H₇₇N₁₇O₁₂
• Molekulargewicht: 1228.36
• MDL-Nummer: MFCD03093472
• UNSPSC-Code: 12352203
• PubChem Substanz-ID: 329817624
• NACRES: NA.32

Eigenschaften

• Qualitätsniveau: 100
• Assay: >97% (HPLC)
• UniProt-Hinterlegungsnummer: P13562
• Lagertemp.: −20°C
• SMILES String: CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CO)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](Cc6c[nH]cn6)NC=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N7CCC[C@H]7C(=O)NCC(N)=O
• InChI: 1S/C60H77N17O12/c1-33(2)21-45(53(83)71-43(13-7-19-65-60(62)63)59(89)77-20-8-14-50(77)58(88)68-29-51(61)81)72-55(85)47(23-35-26-66-41-11-5-3-9-39(35)41)75-54(84)46(22-34-15-17-38(80)18-16-34)73-57(87)49(30-78)76-56(86)48(24-36-27-67-42-12-6-4-10-40(36)42)74-52(82)44(70-32-79)25-37-28-64-31-69-37/h3-6,9-12,15-18,26-28,31-33,43-50,66-67,78,80H,7-8,13-14,19-25,29-30H2,1-2H3,(H2,61,81)(H,64,69)(H,68,88)(H,70,79)(H,71,83)(H,72,85)(H,73,87)(H,74,82)(H,75,84)(H,76,86)(H4,62,63,65)/t43-,44-,45-,46-,47+,48-,49-,50-/m0/s1
• InChIKey: ZZPMMEBSDBNQDQ-NTXUYPKOSA-N
• Angaben zum Gen: mouse ... Gnrh1(14714)

Beschreibung

Amino Acid Sequence

Formyl-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂

Biochem./physiol. Wirkung

Formyl-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂ (Formyl-[D-Trp⁶]-LH-RH Fragment 2-10) is a peptide from GnRH (gonadotropin-releasing hormone) agonist, triptorelin.[1] GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands.[2][3][1] Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.[3] Application of triptorelin suppresses premature LH surge in IVF (in vitro fertilization).[4] Additionally, triptorelin-mediated ovarian suppression in premenopausal women, undergoing chemotherapy for breast cancer, decreases chances of chemotherapy-associated early menopause.[5]

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)