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L5295

Sigma-Aldrich

LY 320135

≥98% (HPLC)

Synonym(e):

4-[6-Methoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl]benzonitrile, LY320135, [6-Methoxy-2-(4-methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)methanone

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About This Item

Empirische Formel (Hill-System):
C24H17NO4
CAS-Nummer:
176977-56-3
Molekulargewicht:
383.40
MDL-Nummer:
MFCD00945878
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329817622
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

orange

Löslichkeit

DMSO: ≥10 mg/mL

Ersteller

Eli Lilly

Lagertemp.

2-8°C

SMILES String

COc1ccc(cc1)-c2oc3cc(OC)ccc3c2C(=O)c4ccc(cc4)C#N

InChI

1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3

InChIKey

RYNSGDFWBJWWSZ-UHFFFAOYSA-N

Biochem./physiol. Wirkung

LY320135 is a potent CB1 receptor antagonist/inverse agonist (Ki = 141 nM) with greater than 70-fold selectivity over CB2 receptors (Ki > 10 μM). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT2 (Ki = 6.4 μM) and muscarinic receptors (Ki = 2.1 μM)

Leistungsmerkmale und Vorteile

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Sigma-Aldrich

A9719

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Sigma-Aldrich

SML1899

SR144528

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