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H6647

Sigma-Aldrich

L-Histidin -dihydrochlorid

≥98% (TLC)

Synonym(e):

(S)-2-Amino-3-(4-imidazolyl)-propanol -dihydrochlorid

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About This Item

Empirische Formel (Hill-System):
C6H11N3O · 2HCl
CAS-Nummer:
1596-64-1
Molekulargewicht:
214.09
Beilstein:
3914853
EG-Nummer:
216-482-2
MDL-Nummer:
MFCD00078058
UNSPSC-Code:
12352209
PubChem Substanz-ID:
24895755
NACRES:
NA.32

product name

L-Histidin -dihydrochlorid, ≥98 (TLC)

Assay

≥98% (TLC)

Form

powder

Farbe

white to off-white

mp (Schmelzpunkt)

198-201 °C (dec.) (lit.)

Anwendung(en)

cell analysis

SMILES String

Cl[H].Cl[H].N[C@H](CO)Cc1c[nH]cn1

InChI

1S/C6H11N3O.2ClH/c7-5(3-10)1-6-2-8-4-9-6;;/h2,4-5,10H,1,3,7H2,(H,8,9);2*1H/t5-;;/m0../s1

InChIKey

FRCAFNBBXRWXQA-XRIGFGBMSA-N

Angaben zum Gen

human ... HRH1(3269)
mouse ... HRH1(15465)
rat ... HRH1(24448)

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Anwendung

L-Histidinol dihydrochloride has been used:
  • as a reagent in urinary metabolite analysis
  • for making DT40 knockout cells, where cells were selected in 1mg/ml histidinol
  • for inducing amino acid deprivation in HepG2 cells

Biochem./physiol. Wirkung

Vorläufer von Histamin; reversibler Inhibitor der Proteinsynthese

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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R C Warrington
Biochemistry and cell biology = Biochimie et biologie cellulaire, 70(5), 365-375 (1992-05-01)
Human cancer chemotherapy is limited by two major problems: the failure of commonly used anticancer drugs to act against tumor cells in a specific manner and the ability of malignant cells to resist killing by antineoplastic agents. Experimentally, both of
David G Meckes et al.
Virology, 398(2), 208-213 (2010-01-07)
The conserved UL16 tegument protein of herpes simplex virus exhibits dynamic capsid-binding properties with a release mechanism that is triggered during initial virus attachment events. In an effort to understand the capsid association and subsequent release of UL16, we sought
Fouzia Sadiq et al.
Nutrition & metabolism, 5, 5-5 (2008-02-14)
Intravenous infusions of glucose and amino acids increase both nitrogen balance and muscle accretion. We hypothesised that co-infusion of glucose (to stimulate insulin) and essential amino acids (EAA) would act additively to improve nitrogen balance by decreasing muscle protein degradation
Ravi K Dinesh et al.
European journal of immunology, 50(3), 380-395 (2019-12-11)
Secondary diversification of the Ig repertoire occurs through somatic hypermutation (SHM), gene conversion (GCV), and class switch recombination (CSR)-three processes that are initiated by activation-induced cytidine deaminase (AID). AID targets Ig genes at orders of magnitude higher than the rest
Sebastian Alers et al.
Autophagy, 7(12), 1423-1433 (2011-10-26)
Under normal growth conditions the mammalian target of rapamycin complex 1 (mTORC1) negatively regulates the central autophagy regulator complex consisting of Unc-51-like kinases 1/2 (Ulk1/2), focal adhesion kinase family-interacting protein of 200 kDa (FIP200) and Atg13. Upon starvation, mTORC1-mediated repression
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