G6416

GW5074

powder

• Synonym(e): 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
• Empirische Formel (Hill-System): C₁₅H₈Br₂INO₂
• CAS-Nummer: 220904-83-6
• Molekulargewicht: 520.94
• MDL-Nummer: MFCD03453076
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278455
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Qualitätsniveau: 100
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: yellow to orange-brown
• Löslichkeit: DMSO: 5 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23
• InChI: 1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
• InChIKey: LMXYVLFTZRPNRV-KMKOMSMNSA-N
• Angaben zum Gen: human ... RAF1(5894)

Beschreibung

Anwendung

GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts,[1] HT-29 colorectal adenocarcinoma cell line [2] and neutrophils.[3]

Biochem./physiol. Wirkung

GW5074 is a cRaf1 kinase inhibitor,[4] which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway.[5] It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.[6]

Sonstige Hinweise

light sensitive

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)