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F8507

Sigma-Aldrich

(±)-Fenfluramine hydrochloride

Synonym(e):

(±)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride

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About This Item

Empirische Formel (Hill-System):
C12H16F3N · HCl
CAS-Nummer:
16105-77-4
Molekulargewicht:
267.72
MDL-Nummer:
MFCD00058016
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24894965

Arzneimittelkontrolle

USDEA Schedule IV

Anwendung(en)

forensics and toxicology

SMILES String

Cl.CCNC(C)Cc1cccc(c1)C(F)(F)F

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H

InChIKey

ZXKXJHAOUFHNAS-UHFFFAOYSA-N

Angaben zum Gen

human ... HTR1D(3352) , HTR2C(3358) , SIGMAR1(10280)

Biochem./physiol. Wirkung

Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

P-Sätze

P301 + P310

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
112K0643
077F0787
052K1359
051K1409
050K1456

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Y X Wang et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1008-1016 (1999-11-24)
Fenfluramine is an indirect agonist of 5-hydroxytryptamine (5-HT) receptors that acts by evoking 5-HT release and blocking 5-HT reuptake in neuronal cells. The current study compared the antinociceptive properties of fenfluramine with those of the tricyclic antidepressants amitriptyline and desipramine
Justin N Siemian et al.
British journal of pharmacology, 175(9), 1519-1534 (2018-02-17)
Although the antinociceptive efficacies of imidazoline I2 receptor agonists have been established, the exact post-receptor mechanisms remain unknown. This study tested the hypothesis that monoaminergic transmission is critical for I2 receptor agonist-induced antinociception. von Frey filaments were used to assess
J D Roth et al.
European journal of pharmacology, 373(2-3), 127-134 (1999-07-22)
Fenfluramine + phentermine was a widely used combination for weight loss. Fenfluramine and phentermine are believed to act via serotonin and catecholamines, respectively. To what extent these drugs interact has not been well-established. We compared the anorectic efficacy of a
Marija Ilic et al.
Frontiers in pharmacology, 11, 673-673 (2020-06-09)
High-affinity monoamine transporters are targets for prescribed medications and stimulant drugs of abuse. Therefore, assessing monoamine transporter activity for candidate medications and newly-emerging drugs of abuse provides essential information for industry, academia, and public health. Radiotracer binding and uptake inhibition
Eileen K Sawyer et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(8), 1816-1824 (2012-03-22)
Acute SSRI (selective serotonin reuptake inhibitor) treatment has been shown to attenuate the abuse-related effects of cocaine; however, SSRIs have had limited success in clinical trials for cocaine abuse, possibly due to neurobiological changes that occur during chronic administration. In
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