No specific suitability tests for cell culture applications have been performed by Sigma. The product is not sterile and has not been tested for endotoxins.
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Wichtige Dokumente
E8750
α-Oestradiol
powder, ≥98% (TLC)
Synonym(e):
α-Estradiol, 1,3,5(10)-Estratrien-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratrien, Epiestradiol
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Größe auswählen
100 MG
CHF 115.00
500 MG
CHF 476.00
1 G
CHF 957.00
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Größe auswählen
Ansicht ändern
100 MG
CHF 115.00
500 MG
CHF 476.00
1 G
CHF 957.00
About This Item
Empirische Formel (Hill-System):
C18H24O2
CAS-Nummer:
Molekulargewicht:
272.38
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
Biologische Quelle
synthetic (organic)
Qualitätsniveau
Assay
≥98% (TLC)
Form
powder
Farbe
white to slight yellow
Löslichkeit
ethanol: 50 mg/mL, clear, colorless
Versandbedingung
ambient
Lagertemp.
room temp
SMILES String
[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
InChIKey
VOXZDWNPVJITMN-SFFUCWETSA-N
Angaben zum Gen
human ... ESR1(2099) , ESR2(2100)
rat ... Ar(24208)
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Biochem./physiol. Wirkung
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A
Lagerklassenschlüssel
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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In modified Tyrode's solution, 17 beta-estradiol at concentrations between 0.1 microgram/ml and 320 nmoles/ml was effective in increasing human spermatozoal forward migration. 17 alpha-Estradiol, although structurally similar to 17 beta-estradiol, had no effect on human spermatozoal motility. DL-Norgestrel at concentrations
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Is Product E8750, α-Estradiol, tested in cell culture?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the difference between α-Estradiol (Product No. E8750) and β-Estradiol?
1 answer-
α-Estradiol has been reported as being less feminizing than β-Estradiol while still having significant biological properties. See Moos, W.H., et al, "17α-Estradiol:a less-feminizing estrogen", Drug Development Research, 69(4), 177-184 (2008).
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How can I dissolve α-Estradiol, Product No. E8750?
1 answer-
This chemical is soluble in ethanol at 50 mg/mL with heating, and in DMSO at 27 mg/mL. Use of freshly prepared solutions is recommended.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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