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D-073

Supelco

5α-Dihydrotestosteron (DHT) -Lösung

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(e):

5-α-Dihydrotestosteron -Lösung, 5-alpha-Dihydrotestosteron, DHT, Dihydrotestosteron, 5α−DHT -Lösung

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1 ML
CHF 181.00

CHF 181.00

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1 ML
CHF 181.00

About This Item

Empirische Formel (Hill-System):
C19H30O2
CAS-Nummer:
521-18-6
Molekulargewicht:
290.44
MDL-Nummer:
MFCD00003667
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329798632
NACRES:
NA.24

CHF 181.00

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Qualität

certified reference material

Qualitätsniveau

300

Form

liquid

Leistungsmerkmale

Snap-N-Spike®/Snap-N-Shoot®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

Konzentration

1.0 mg/mL in methanol

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

clinical testing
clinical testing

Format

single component solution

Lagertemp.

−70°C

SMILES String

C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1

InChIKey

NVKAWKQGWWIWPM-ABEVXSGRSA-N

Verwandte Kategorien

Allgemeine Beschreibung

Diese Certified Spiking Solution® eignet sich für GC/MS- und LC/MS-Anwendungen, von klinischen und diagnostischen Tests über die Endokrinologie bis hin zu Tests im Sport.

5α-Dihydrotestosteron (DHT) ist ein Steroidhormon und Metabolit des natürlich vorkommenden Androgens Testosteron, das durch die Wirkung des NADPH-abhängen Enzyms 5α-Reduktase gebildet wird. Es ist an einer Reihe von Erkrankungen von männlichem Haarausfall über benigne Prostatahyperplasie bis hin zu Prostatakarzinom beteiligt. Als anaboles Steroid wird DHT auch als leistungssteigerndes Mittel verwendet, um das Muskelwachstum zu fördern.

Anwendung

Das zertifizierte Referenzmaterial (ZRM) in Lösung kann auch wie folgt verwendet werden:
  • Gleichzeitige Analyse von Testosteron und 5α-Dihydrotestosteron mit einem Gaschromatografie-Massenspektrometrie-Tischgerät (GC-MS) in Humanserumproben
  • Flüssigchromatografie-Elektrospray-Ionisation-Tandem-Massenspektrometrie(LC/ESI-MS/MS)-Bestimmung von Testosteron und 5α-Dihydrotestosteron nach ihrer protonaffinitiven Derivatisierung mit Picolinsäure und ihren Analoga
  • Bestimmung von Testosteron und 5α-Dihydrotestosteron in Plasma- und Hodenproben von Amerikanische Dickkopfelritze mittels Gaschromatografie-Tandem-Massenspektrometrie (GC-MS/MS)
  • Multirückstandsanalyse von Epitestosteron, Testosteron, 5α-Dihydrotestosteron, Dehydroepiandrosteron, Androsteron und Etiocholanolon in Urinproben mittels hochauflösender Full-Scan-Elektrospray-Ionisation-Flüssigchromatografie (HR-FS-ESI-LC) in Kombination mit einem Quadrupol-Orbitrap-Massenspektrometer (Q/Orbitrap-MS) gemäß den Anforderungen der Welt-Anti-Doping-Agentur (WADA)
  • Quantitative Analyse von neun Hydroxy-Androgenen und deren Konjugaten durch ein Verfahren auf der Grundlage von stabile Isotopenverdünnung-Flüssigchromatografie-Elektrospray-Ionisation-Tandem-Massenspektrometrie (SID-LC-ESI-MS/MS) nach ihrer Derivatisierung mit Picolinsäure

Leistungsmerkmale und Vorteile

  • Vollständig charakterisiert unter ISO/IEC 17025 und ISO 17034-Akkreditierung
  • Wird mit einem umfassenden Analysenzertifikat (CoA) geliefert, das Daten zu Stabilität, Homogenität, Genauigkeit der Konzentration, Messunsicherheit und Rückverfolgbarkeit enthält
  • Durch Echtzeit-Stabilitätsstudien streng geprüft, um Genauigkeit und Haltbarkeit sicherzustellen
  • Mittels qualifizierten Präzisionswaagen gravimetrisch hergestellt, um minimale Messunsicherheit sicherzustellen
  • Für lange Haltbarkeit unter Argon in Ampullen schmelzversiegelt
  • Wird in einem praktischen, DEA-befreiten Format bereitgestellt, um die Laboreffizienz zu steigern

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes,Central nervous system

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 2

Flammpunkt (°F)

49.5 °F - closed cup

Flammpunkt (°C)

9.7 °C - closed cup

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Analysenzertifikate (COA)

Lot/Batch Number

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Die Dokumentenbibliothek aufrufen

Paula M Marchetti et al.
Annals of clinical biochemistry, 50(Pt 2), 95-107 (2013-02-23)
Dihydrotestosterone (DHT) is the most potent natural androgen in humans. There has been an increasing interest in this androgen and its role in the development of primary and secondary sexual characteristics as well as its potential roles in diseases ranging
Paulo A Saldanha et al.
Clinical and experimental pharmacology & physiology, 40(3), 181-189 (2013-01-03)
The aim of the present study was to determine the effects of androgens in the regulation of human umbilical artery (HUA) contractility. The short-term effects of testosterone on the tone of the HUA were investigated, as were the long-term effects
Juan Wen et al.
The Prostate, 73(10), 1069-1081 (2013-02-21)
Androgen modulation of angiogenesis in prostate cancer may be not directly mediated by androgen receptor (AR) as AR is not detected in the prostatic endothelial cells. We examined the paracrine stimulation of cell proliferation by prostate tumor cells and its
Noboru Hara et al.
Urology, 81(2), 376-380 (2013-02-05)
To elucidate the mechanism of the androgen deprivation therapy (ADT)-related decrease in lean body mass (LBM). The LBM and blood samples were studied before and after 6 months of ADT in 72 patients with localized prostate cancer. The LBM was
Julia Johansson et al.
PloS one, 8(1), e54357-e54357 (2013-01-26)
In rats with dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS), repeated low-frequency electrical stimulation of acupuncture needles restores whole-body insulin sensitivity measured by euglycemic hyperinsulinemic clamp. We hypothesized that electrical stimulation causing muscle contractions and manual stimulation causing needle sensation have
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Questions

1–5 of 5 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Does this DHT cross react between humans and mice? cat #: D-073-1ML

    1 answer

    1. DHT exhibits cross-reactivity between humans and mice, but biological effects and responses may differ due to species-specific differences. This product is an analytical standard and is not intended for animal studies.

      Helpful?

  4. Is this suitable for cell culture?

    1 answer

    1. This product is prepared in methanol, which would be toxic to cells. Currently, there is no cell culture tested product option available. However, product A8380, the powder form, has been used successfully in cell culture applications. Please see the link below to review this product. Note the Peer Reviewed Papers section lists a number of applicable publications.
      https://www.sigmaaldrich.com/product/sigma/a8380

      Helpful?

  5. hi, am I right in thinking that D-073 arrives in 1mL vials and they are to be stored long term at -70C. We only have -80C freezers, do you see that as a problem?

    1 answer

    1. The product COA (https://www.sigmaaldrich.com/certificates/Graphics/COfAInfo/fluka/pdf/cer/D-073_FE02172263.pdf) indicates on page 10 that it is okay to store this material for long term stability at -60C to -80C, so the indicated freezer/temperature should be fine.

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