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C8417

Sigma-Aldrich

N-(2-Chlorethyl)-N-Ethyl-2-Brombenzylamin -hydrochlorid

≥98% (TLC), solid, adrenergic neurotoxin

Synonym(e):

DSP-4

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About This Item

Empirische Formel (Hill-System):
C11H15BrClN · HCl
CAS-Nummer:
40616-75-9
Molekulargewicht:
313.06
Beilstein:
4020910
MDL-Nummer:
MFCD00043241
UNSPSC-Code:
12352116
PubChem Substanz-ID:
24277753
NACRES:
NA.77

product name

N-(2-Chlorethyl)-N-Ethyl-2-Brombenzylamin -hydrochlorid, ≥98%, solid

Qualitätsniveau

200

Assay

≥98%

Form

solid

Farbe

white

Löslichkeit

H2O: 48 mg/mL
0.1 M NaOH: 7 mg/mL
ethanol: soluble

SMILES String

Cl[H].CCN(CCCl)Cc1ccccc1Br

InChI

1S/C11H15BrClN.ClH/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12;/h3-6H,2,7-9H2,1H3;1H

InChIKey

NDDRNRRNYOULND-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Adrenergic neurotoxin that induces acute and relatively selective degeneration of both central and peripheral noradrenergic nerve terminals.

Vorsicht

Hygroscopic.

Angaben zur Herstellung

Solutions in ethanol, water or 0.1 N NaOH should be freshly prepared.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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T Skrebuhhova et al.
Methods and findings in experimental and clinical pharmacology, 21(7), 483-490 (1999-11-02)
[3H]-Ketanserin binding in rat neocortex (frontal and cerebral cortex) after 3-week treatment with desipramine (10 mg/kg) and citalopram (5 mg/kg) in vehicle-, DSP-4- (50 mg/kg) and p-CPA- (350 mg/kg before the beginning of experiments and once per week on the
Yun-Fei Lü et al.
Frontiers in neural circuits, 11, 66-66 (2017-10-06)
Empathy for pain (vicariously felt pain), an ability to feel, recognize, understand and share the painful emotions of others, has been gradually accepted to be a common identity in both humans and rodents, however, the underlying neural and molecular mechanisms
Delphine Guérin et al.
Behavioral neuroscience, 122(4), 816-826 (2008-08-30)
Noradrenergic projections from the locus coeruleus (LC) project to the olfactory bulb (OB), a cortical structure implicated in odor learning and perceptual differentiation among similar odorants. The authors tested the role of OB noradrenaline (NA) in short-term olfactory memory using
Maria Vittoria Simonini et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 5(2), 252-259 (2009-12-04)
The endogenous neurotransmitter noradrenaline (NA) is known to exert potent anti-inflammatory effects in glial cells, as well as provide neuroprotection against excitatory and inflammatory stimuli. These properties raise the possibility that increasing levels of NA in the central nervous system
Clement Hamani et al.
Biological psychiatry, 67(2), 117-124 (2009-10-13)
Subcallosal cingulate gyrus (SCG) deep brain stimulation (DBS) is being investigated as a treatment for major depression. We report on the effects of ventromedial prefrontal cortex (vmPFC) DBS in rats, focusing on possible mechanisms involved in an antidepressant-like response in
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