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C0563

Sigma-Aldrich

Cardiolipin Natriumsalz aus Rinderherz

≥97% (TLC), lyophilized powder

Synonym(e):

Diphosphatidylglycerin

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10 MG
CHF 106.00
25 MG
CHF 188.00
100 MG
CHF 571.00
500 MG
CHF 2’180.00

CHF 106.00

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10 MG
CHF 106.00
25 MG
CHF 188.00
100 MG
CHF 571.00
500 MG
CHF 2’180.00

About This Item

MDL-Nummer:
MFCD00071040
UNSPSC-Code:
12352211
NACRES:
NA.25

CHF 106.00

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Bulk-Bestellung anfordern

Biologische Quelle

bovine heart

Qualitätsniveau

200

Assay

≥97% (TLC)

Form

lyophilized powder

Lipid-Typ

phosphoglycerides

Versandbedingung

ambient

Lagertemp.

−20°C

Verwandte Kategorien

Allgemeine Beschreibung

Cardiolipin ist in der inneren Membran der Mitochondrien lokalisiert. Es enthält 18 Kohlenstoffatome, 3-Phosphatidylgruppen, die über eine Glycerinbrücke verbunden sind. Cardiolipin ist ein wichtiger Bestandteil des Enzyms ATP-Synthase.[1]

Anwendung

Cardiolipin-Natriumsalz aus Rinderherz wird verwendet:
  • als Phospholipidstandard in der Dünnschichtchromatographie zur Quantifizierung der gesamten mitochondrialen Lipide von Neurospora crassa (89)
  • als interner Standard in der Umkehrphasen-Hochleistungsflüssigkeitschromatographie (RP-HPLC) zur Quantifizierung von bakteriellen Lipidextrakten (90)
  • als Antigen zur Beurteilung der IgM-Reaktion bei Patienten mit systemischem Lupus erythematodes (SLE) (91)

Biochem./physiol. Wirkung

Cardiolipin ist ein mitochondriales Phospholipid, das in niedrigen Konzentrationen in Säugetiergeweben vorzufinden ist. Häufig handelt es sich dabei um eine Membrankomponente. Hemmt die Zellanhaftung von Fibronektin, Vitronektin und Typ-I-Kollagen.

Verpackung

Verpackt unter Argon

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000377321
0000372460
0000372466
0000361777
0000348945

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Epstein-Barr virus antibodies mark systemic lupus erythematosus and scleroderma patients negative for anti-DNA
Fattal I, et al.
Immunology, 141(2), 276-285 (2014)
Val A Fajardo et al.
Scientific reports, 7(1), 2060-2060 (2017-05-19)
Cardiolipin (CL) is a unique mitochondrial phospholipid that, in skeletal muscle, is enriched with linoleic acid (18:2n6). Together, CL content and CL 18:2n6 composition are critical determinants of mitochondrial function. Skeletal muscle is comprised of slow and fast fibers that
Effects of pure n-alkanes and crude oil on bacterial phospholipid classes and molecular species determined by electrospray ionization mass spectrometry
Mazzella N, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 822(1-2), 40-53 (2005)
Lu Luo et al.
The Journal of biological chemistry, 289(46), 31708-31718 (2014-10-08)
Bax is a pro-apoptotic Bcl-2 family protein. The activated Bax translocates to mitochondria, where it forms pore and permeabilizes the mitochondrial outer membrane. This process requires the BH3-only activator protein (i.e. tBid) and can be inhibited by anti-apoptotic Bcl-2 family
Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to beta-barrel protein assembly and maintenance of mitochondrial morphology
Wideman JG, et al.
PLoS ONE, 8(8), e71837-e71837 (2013)
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. According to your COA for item C0563, Cardiolipin protein, the purity was tested by TLC; what are the specific test methods and experimental conditions?

    1 answer

    1. This product is classified at an MQ 200 level. We are unable to provide the analytical method for products classified below an MQ 400. However, general conditions may be shared.
      Sample Concentration - 50 mg/ml
      Solvent - Chloroform
      Detection - Stahl's 214
      Markers - Linoleic acid and Linoleic acid methyl ester

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