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A7611

Sigma-Aldrich

Azelastin -hydrochlorid

≥98% (HPLC)

Synonym(e):

4-[(4-Chlorphenyl)-methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-on -hydrochlorid, Astelin, Optivar

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CHF 78.40
50 MG
CHF 311.00

CHF 78.40

Voraussichtliches Versanddatum26. Mai 2025

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10 MG
CHF 78.40
50 MG
CHF 311.00

About This Item

Empirische Formel (Hill-System):
C22H24ClN3O · HCl
CAS-Nummer:
79307-93-0
Molekulargewicht:
418.36
MDL-Nummer:
MFCD00242783
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329770938
NACRES:
NA.77

CHF 78.40

Voraussichtliches Versanddatum26. Mai 2025

Bulk-Bestellung anfordern

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to off-white

Löslichkeit

DMSO: >10 mg/mL

Ersteller

Wallace

Lagertemp.

−20°C

SMILES String

Cl.CN1CCCC(CC1)N2N=C(Cc3ccc(Cl)cc3)c4ccccc4C2=O

InChI

1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H

InChIKey

YEJAJYAHJQIWNU-UHFFFAOYSA-N

Angaben zum Gen

human ... HRH1(3269)

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Anwendung

Azelastine hydrochloride is a H1 histamine receptor antagonist and NF-kB activator. Azelastine hydrochloride has been used in a study to investigate the potential of polymeric microspheres for treatment of allergic conjunctivitis.

Biochem./physiol. Wirkung

H1 Histamin-Rezeptor-Antagonist, NF-kB-Aktivator.

Leistungsmerkmale und Vorteile

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wallace. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000247045
030M4702V
030M47021V
030M4702

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Carsten Gründemann et al.
Journal of ethnopharmacology, 145(1), 118-126 (2012-11-13)
Extracts from Veronica officinalis L. are traditionally used for the treatment of lung diseases; however, the effective compounds and the mode of action are still unknown. Here we analyzed the effects of a standardized Veronica extract on genes expression and
Eli O Meltzer et al.
Allergy and asthma proceedings, 33(4), 324-332 (2012-08-04)
Many patients with allergic rhinitis (AR) have uncontrolled symptoms despite available treatment options. This study was designed to evaluate the efficacy and safety of MP29-02 (a novel intranasal formulation of fluticasone propionate [FP] and azelastine [AZ] hydrochloride), compared with monotherapy
Demin Han et al.
ORL; journal for oto-rhino-laryngology and its related specialties, 73(5), 260-265 (2011-08-13)
To compare the onset of action, efficacy, and safety of azelastine and levocabastine in the treatment of allergic rhinitis. In a multicenter, randomized, double-blind, parallel-group trial, 244 patients with moderate-to-severe allergic rhinitis were randomized to receive either azelastine hydrochloride nasal
Jonathan A Bernstein
Current medical research and opinion, 23(10), 2441-2452 (2007-08-29)
Azelastine hydrochloride (Astelin) nasal spray 0.1% solution is a second-generation intranasal antihistamine available in the US for treatment of both seasonal allergic rhinitis (SAR) and nonallergic vasomotor rhinitis (VMR). Searches of journal articles including the title word 'azelastine' from 1979
Warner W Carr et al.
Allergy and asthma proceedings, 33(6), 450-458 (2012-11-07)
Intranasal corticosteroids are considered the most effective therapy for moderate-to-severe seasonal allergic rhinitis (SAR) and recommended first line in guidelines. It is uncertain whether intranasal antihistamines have comparable efficacy. This study was designed to compare the efficacy of azelastine (AZE;
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