479M-9

MDM2 (IF2) Mouse Monoclonal Antibody

• Synonym(e): Mouse double minute protein 2
• UNSPSC-Code: 12352203

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100; 500
• Konjugat: unconjugated
• Antikörperform: culture supernatant
• Antikörper-Produkttyp: primary antibodies
• Klon: IF2, monoclonal
• Beschreibung: For In Vitro Diagnostic Use in Select Regions
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Verpackung: vial of 0.1 mL concentrate (479M-94); vial of 0.1 mL concentrate Research Use Only (479M-94-RUO); vial of 0.5 mL concentrate (479M-95); vial of 1.0 mL concentrate (479M-96); vial of 1.0 mL concentrate Research Use Only (479M-96-RUO); vial of 1.0 mL pre-dilute Research Use Only (479M-97-RUO); vial of 1.0 mL pre-dilute ready-to-use (479M-97); vial of 7.0 mL pre-dilute ready-to-use (479M-98); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (479M-98-RUO)
• Hersteller/Markenname: Cell Marque^®
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• Isotyp: IgG
• Kontrolle: dedifferentiated liposarcoma, well-differentiated liposarcoma
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• Visualisierung: nuclear

Beschreibung

Allgemeine Beschreibung

Mouse double minute protein 2 (MDM2) is a gene encoded on the 12q13-14 chromosomal sequence.1-5 It encodes for a 483 amino acid residue protein which binds to the amino-terminal transcription region of p53.^2,5 MDM2 has been shown to negatively regulate the tumor-suppressor activity of p53 by three mechanisms: Blocking p53 transcription, binding to p53 causing it to be exported from the nucleus, and accelerating the destruction of p53.¹ MDM2 up-regulation has been shown in liposarcoma while being absent in lipoma.^2,4 Therefore, anti-MDM2 has been demonstrated to be a potentially useful tool in distinguishing well-differentiated liposarcoma (atypical lipomatous tumor) from lipoma, with the neoplastic cells positive in the former lesion and negative in lipoma.^2,4

Qualität

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Angaben zur Herstellung

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Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: [email protected]

Rechtliche Hinweise

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany