SMB01318

3-Hydroxydesloratadine

• Synonym(e): 3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity
• Empirische Formel (Hill-System): C₁₉H₁₉ClN₂O
• CAS-Nummer: 119410-08-1
• Molekulargewicht: 326.82
• MDL-Nummer: MFCD00878381
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Beschreibung: Modulation and Signaling
• Qualitätsniveau: 100
• Assay: ≥90%
• Form: solid
• Methode(n): HPLC: suitable
• Farbe: pale yellow to off-white
• Lagertemp.: −20°C
• SMILES String: Clc1cc2c(cc1)C(=C4CCNCC4)c3ncc(cc3CC2)O
• InChI: 1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
• InChIKey: NDFMTPISBHBIKE-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.

Anwendung

3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research

Biochem./physiol. Wirkung

3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite[1].

Leistungsmerkmale und Vorteile

• High quality compound suitable for multiple research applications
• Compatible with a wide variety of chromatographic and spectrometry techniques

Sonstige Hinweise

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This product is intended for research purposes only, and it is not meant for human consumption.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable