The primary difference between the products is the testing. Product P0972 is USP tested, product P4932 is tested against 3 mammalian cell lines to make sure it is not toxic to the cells, product P4119 is cell culture and endotoxin tested, and products P1004 and 81334 are the research grades with P1004 in USP units and 81334 in international units.
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Wichtige Dokumente
P0972
Polymyxin B -sulfat
meets USP testing specifications
Synonym(e):
Polymyxin B -sulfat (Salz)
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1000000 UNITS
CHF 75.00
10000000 UNITS
CHF 372.00
50000000 UNITS
CHF 1’320.00
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1000000 UNITS
CHF 75.00
10000000 UNITS
CHF 372.00
50000000 UNITS
CHF 1’320.00
About This Item
Empirische Formel (Hill-System):
C55H96N16O13 · 2H2SO4
CAS-Nummer:
Molekulargewicht:
1385.61
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352209
NACRES:
NA.21
Empfohlene Produkte
Agentur
USP/NF
meets USP testing specifications
Qualitätsniveau
Form
powder
Wirkungsspektrum von Antibiotika
Gram-negative bacteria
Gram-positive bacteria
fungi
Anwendung(en)
pharmaceutical (small molecule)
Wirkungsweise
cell membrane | interferes
Lagertemp.
2-8°C
SMILES String
O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChIKey
HNDFYNOVSOOGDU-UHFFFAOYSA-N
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Verwandte Kategorien
Allgemeine Beschreibung
Chemical structure: peptide
Anwendung
Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Biochem./physiol. Wirkung
Wirkungsweise: Polymyxin-B-Sulfat bindet an den Lipid-A-Teil der bakteriellen Lipopolysaccharide† und unterbricht die Zytoplasmamembran durch Bildung von Poren, die groß genug sind, um einen Nukleotidaustritt durch die Bakterienwände zu ermöglichen. Dadurch wird die Durchlässigkeit der Zytoplasmamembran gestört.
Antimikrobielles Spektrum: Hat eine bakterizide Wirkung auf die meisten gramnegativen Stäbchen††, einschließlich E. coli, sowie auf die meisten Pilze und grampositiven Bakterien.
Antimikrobielles Spektrum: Hat eine bakterizide Wirkung auf die meisten gramnegativen Stäbchen††, einschließlich E. coli, sowie auf die meisten Pilze und grampositiven Bakterien.
Verpackung
This product is packaged in a bottomless glass bottle, with its contents inside an inserted fused cone.
Vorsicht
As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Oral
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Kunden haben sich ebenfalls angesehen
Martti Vaara et al.
The Journal of antimicrobial chemotherapy, 73(2), 452-455 (2017-11-18)
Extremely multiresistant strains of Enterobacteriaceae, such as those of Escherichia coli and Klebsiella pneumoniae, are emerging and spreading at a worrisome speed. Polymyxins (polymyxin B, colistin) are used as last-line therapy against such strains, in spite of their notable nephrotoxicity
Mei-Ling Han et al.
ACS chemical biology, 13(1), 121-130 (2017-11-29)
Polymyxins are last-line antibiotics against life-threatening multidrug-resistant Gram-negative bacteria. Unfortunately, polymyxin resistance is increasingly reported, leaving a total lack of therapies. Using lipidomics and transcriptomics, we discovered that polymyxin B induced lipid A deacylation via pagL in both polymyxin-resistant and
Martti Vaara et al.
Peptides, 91, 8-12 (2017-03-17)
Recent years have brought in an increased interest to develop improved polymyxins. The currently used polymyxins, i.e. polymyxin B and colistin (polymyxin E) are pentacationic lipopeptides that possess a cyclic heptapeptide part with three positive charges, a linear "panhandle" part
Amit Kumar et al.
Scientific reports, 7, 39925-39925 (2017-01-05)
To become clinically effective, antimicrobial peptides (AMPs) should be non-cytotoxic to host cells. Piscidins are a group of fish-derived AMPs with potent antimicrobial and antiendotoxin activities but limited by extreme cytotoxicity. We conjectured that introduction of cationic residue(s) at the
Sara N Vallerie et al.
PloS one, 3(9), e3151-e3151 (2008-09-06)
It has been established that c-Jun N-terminal kinase 1 (JNK1) is essential to the pathogenesis of insulin resistance and type 2 diabetes. Although JNK influences inflammatory signaling pathways, it remains unclear whether its activity in macrophages contributes to adipose tissue
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I see that you list several Polymyxin B Sulfate products (P0972, P1004, P4932, 81334 and P4119). What are the differences?
1 answer-
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What is MU and how does this relate to milligrams?
1 answer-
MU is million units. You can convert this to mg by dividing package size by the unit activity listed on the Certificate of Analysis for your specific lot.
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What is the solution stability of Product P0972, Polymyxin B sulfate?
1 answer-
For solution stability information, please refer to the product information sheet for a related Polymyxin B sulfate product (Product No. P1004).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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