N5535

Niacinamid

meets USP testing specifications

• Synonym(e): Nicotinamid, Niacinamid, Nicotinsäureamid, Pyridin-3-carbonsäureamid, Vitamin B₃, Vitamin PP
• Empirische Formel (Hill-System): C₆H₆N₂O
• CAS-Nummer: 98-92-0
• Molekulargewicht: 122.12
• Beilstein: 383619
• EG-Nummer: 202-713-4
• MDL-Nummer: MFCD00006395
• UNSPSC-Code: 12352205
• PubChem Substanz-ID: 24897740
• NACRES: NA.21

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Agentur: USP/NF; meets USP testing specifications
• Assay: 98.5-101.5% dry basis
• Form: crystals
• Farbe: white
• mp (Schmelzpunkt): 128-131 °C (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• SMILES String: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
• InChIKey: DFPAKSUCGFBDDF-UHFFFAOYSA-N
• Angaben zum Gen: human ... PARP1(142) , SIRT2(22933)

Beschreibung

Allgemeine Beschreibung

Niacinamide, also known as 3-pyridinecarboxamide, is a water soluble vitamin. It is widely present in plants, animal food and cosmetics.

Anwendung

Niacinamide has been used:

• as a component of islet maturation culture media
• to induce differentiation of insulin secreting cells
• to compare its preclinical effectiveness with that of progesterone

Biochem./physiol. Wirkung

Nicotinamid ist ein Amid-Derivat von Vitamin B3 und ein PARP-Inhibitor.

Niacinamide is a primary precursor of nicotinamide adenine dinucleotide (NAD⁺), which is an important coenzyme in adenosine triphosphate (ATP) production. Nicotinamide deficiency is associated with pellagra.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H319
• P-Sätze: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): 302.0 °F - closed cup
• Flammpunkt (°C): 150 °C - closed cup
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves