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BP460

Nicotinamid

British Pharmacopoeia (BP) Reference Standard

Synonym(e):

Niacinamid, Nicotinsäureamid, Pyridin-3-carbonsäureamid, Vitamin B3, Vitamin PP

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About This Item

Empirische Formel (Hill-System):
C6H6N2O
CAS-Nummer:
Molekulargewicht:
122.12
Beilstein:
383619
MDL-Nummer:
UNSPSC-Code:
41116107
NACRES:
NA.24

Qualität

pharmaceutical primary standard

Agentur

BP

API-Familie

nicotinamide

Form

solid

Hersteller/Markenname

BP

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp (Schmelzpunkt)

128-131 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

−20°C

SMILES String

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChIKey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Nicotinamide, a member of the family of water-soluble B vitamins, is generally produced from nicotinic acid (vitamin B3). It is often present in food products. It has been reported to have been effective in the treatment of pellagra, psoriasis, schizophrenia, and type I diabetes. It is also shown to possess anti-inflammatory activity.

Anwendung

Nicotinamide BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Vitamins B and C Injection
  • Nicorandil Tablets
  • Biochem./physiol. Wirkung

    Nicotinamid ist ein Amid-Derivat von Vitamin B3 und ein PARP-Inhibitor.

    Verpackung

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Sonstige Hinweise

    Sales restrictions may apply.

    Piktogramme

    Exclamation mark

    Signalwort

    Warning

    H-Sätze

    Gefahreneinstufungen

    Eye Irrit. 2

    Lagerklassenschlüssel

    11 - Combustible Solids

    WGK

    WGK 1

    Flammpunkt (°F)

    302.0 °F - closed cup

    Flammpunkt (°C)

    150 °C - closed cup


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    Analysenzertifikate (COA)

    Lot/Batch Number

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    Kunden haben sich ebenfalls angesehen

    Evaluation of analytical tools and multivariate methods for quantification of co-former crystals in ibuprofen-nicotinamide co-crystals
    Soares FLF and Carneiro RL
    Journal of Pharmaceutical and Biomedical Analysis, 89, 166-175 (2014)
    Development of a validated HPLC method for the determination of B-complex vitamins in pharmaceuticals and biological fluids after solid phase extraction
    Chatzimichalakis PF, et al.
    Journal of Separation Science, 27(14), 1181-1188 (2004)
    Nicotinamide
    European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
    European pharmacopoeia, 14(4), 3145-3146 (2017)
    Simultaneous determination and classification of riboflavin, thiamine, nicotinamide and pyridoxine in pharmaceutical formulations, by UV-visible spectrophotometry and multivariate analysis
    Lopez-de-Alba LP, et al.
    Journal of the Brazilian Chemical Society, 17(4), 715-722 (2006)
    Youdan Shi et al.
    International immunopharmacology, 14(4), 530-537 (2012-10-13)
    Nicotinamide (NAM), the amide form of vitamin B3, is involved in a wide range of biological processes. Recent evidence revealed the anti-inflammatory and anti-oxidant properties of NAM and suggests it may be used as a novel strategy in the prevention

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