94687

Everolimus

analytical standard

• Synonym(e): 42-O-(2-Hydroxyethyl)-rapamycin
• Empirische Formel (Hill-System): C₅₃H₈₃NO₁₄
• CAS-Nummer: 159351-69-6
• Molekulargewicht: 958.22
• MDL-Nummer: MFCD00929329
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: analytical standard
• Qualitätsniveau: 100
• Assay: ≥75.0% (qNMR)
• Haltbarkeit: limited shelf life, expiry date on the label
• Anwendung(en): clinical testing
• Format: neat
• Lagertemp.: −20°C
• SMILES String: O=C(C([C@@]1(O)[C@H](C)CC[C@](C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C2=O)([H])O1)=O)N3[C@H](C(O[C@@]([C@@H](C[C@@]4([H])C[C@@H](OC)[C@H](OCCO)CC4)C)([H])CC([C@H](C)/C=C(C)/[C@@H](O)[C@H]2OC)=O)=O)CCCC3
• InChI: 1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
• InChIKey: HKVAMNSJSFKALM-GKUWKFKPSA-N
• Angaben zum Gen: human ... FKBP1A(2280)

Beschreibung

Allgemeine Beschreibung

Everolimus (RAD001), a derivative of rapamycin, is commonly used as a drug for the inhibition of the mTOR pathway, affecting tumor cell division and angiogenesis.

Anwendung

Everolimus may be used as a standard in the following clinical studies:

• Investigation of its glucose-dependent growth-inhibitory property in breast cancer cell lines.
• Evaluate its possible antiproliferative effects in human bronchial carcinoids in primary culture.

Sicherheitshinweise

• Piktogramme: GHS08,GHS09
• Signalwort: Warning
• H-Sätze: H351,H361fd,H373,H410
• P-Sätze: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Gefahreneinstufungen: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 2 - STOT RE 2
• Zielorgane: Kidney,Testes
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable