67667

Kynurensäure

analytical standard

• Synonym(e): 4-Hydroxychinolin-2-carboxylsäure
• Empirische Formel (Hill-System): C₁₀H₇NO₃
• CAS-Nummer: 492-27-3
• Molekulargewicht: 189.17
• Beilstein: 147451
• EG-Nummer: 207-751-5
• MDL-Nummer: MFCD00006753
• UNSPSC-Code: 41116107

Eigenschaften

• Qualität: analytical standard
• Assay: ≥98.0% (HPLC)
• Haltbarkeit: limited shelf life, expiry date on the label
• mp (Schmelzpunkt): 275 °C (dec.) (lit.)
• Anwendung(en): clinical testing
• SMILES String: OC(=O)c1cc(O)c2ccccc2n1
• InChI: 1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
• InChIKey: HCZHHEIFKROPDY-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Kynurenic acid, a tryptophan metabolite,[1][2] is a naturally occurring NMDA-receptor and an α7 nicotinic acetylcholine receptor antagonist in the human brain with preferential action at both of the glycine (Gly) binding sites of the N-methyl D-aspartate (NMDA)[2] and α7 nicotinic acetylcholine receptors.[3] This implies that the compound can have a physiological interaction with glutaminergic and cholinergic neurotransmission in the brain.[2][3] Kynurenic acid is reported to be found in elevated levels in the cerebrospinal fluid of patients with schizophrenia.[2] Its anticonvulsant and neuroprotective properties are experimentally reported.[4]

Anwendung

Kynurenic acid may be used as an analytical standard for the quantification of the analyte in serum samples,[3][5] food and honeybee products[4] using high-performance liquid chromatography with fluorescence detection.

Empfohlene Produkte

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable