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Merck

10602361001

Roche

Plasmin, human

from human plasma

Synonym(e):

Plasmin

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About This Item

EC-Nummer:
UNSPSC-Code:
12352204

Biologische Quelle

human plasma

Qualitätsniveau

Assay

95% (electrophoresis)

Form

suspension

Spezifische Aktivität

~8 units/mg protein (At 25 °C with Chromozym PL as the substrate.)

Mol-Gew.

Mr ~85 kDa

Verpackung

pkg of 0.5 mL (5 U)

Hersteller/Markenname

Roche

Optimaler pH-Wert

8.9

Versandbedingung

wet ice

Allgemeine Beschreibung

Inhibitors: DFP, PMSF, TLCK, leupeptin, aprotinin, soybean trypsin inhibitor, α1-antitrypsin, α2-macroglobulin, anti-thrombin III heparin, APMSF, and α2-antiplasmin
Fibrinolysin

Spezifität

Serine endopeptidase that hydrolyzes peptide and ester bonds at the carboxylic side of Lys or Arg; more selective than trypsin.

Anwendung

Human plasmin has been used as an oligopeptide substrate in peptidase inhibition assays.

Biochem./physiol. Wirkung

Plasmin is a direct acting fibrinolytic enzyme present in blood. Its activity is independent of plasminogen presence during fibrinolysis. Plasmin is rapidly and irreversibly inhibited by α-2 antiplasmin.

Physikalische Form

Suspension in 3.2 M ammonium sulfate solution

Angaben zur Herstellung

Stabilizers: Human plasmin does not contain stabilizers.
Storage conditions (working solution): 2 to 8 °C
Diluted solution (pH 8.6) is stable at 2 to 8 °C for at least 1–2 weeks. For storage of dialyzed solution freezing in aliquots is recommended.

Lagerung und Haltbarkeit

Store at 2 to 8 °C. (Recommended form for storage is ammonium sulfate suspension 3.2 M, pH 8.6.)

Sonstige Hinweise

For life science research only. Not for use in diagnostic procedures.

Haftungsausschluss

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Piktogramme

Corrosion

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Eye Dam. 1 - Skin Corr. 1B

Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

No data available

Flammpunkt (°C)

No data available


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Identification and partial characterization of a novel serpin from Eudiplozoon nipponicum (Monogenea, Polyopisthocotylea
Roudnicky P, et al.
Parasite (Paris, France) (2018)
A novel Kunitz protein with proposed dual function from Eudiplozoon nipponicum (Monogenea) impairs haemostasis and action of complement in vitro
Jedlikova L, et al.
International Journal For Parasitology (2019)
Jialu Liu et al.
NPJ Regenerative medicine, 7(1), 34-34 (2022-07-01)
The biomaterial fibrin is widely used as a clinical tissue sealant in surgery. In preclinical research, fibrin is also extensively studied as a carrier material for growth factor delivery. In these applications, premature fibrin degradation leads to recurrent bleeding, tissue
R D Shlansky-Goldberg et al.
Journal of thrombosis and haemostasis : JTH, 6(6), 944-950 (2008-04-04)
Hemodialysis (HD) grafts often fail because of stenosis at the venous anastomosis and thrombotic occlusion. Percutaneous management relies on thrombolysis with plasminogen activators, mechanical removal of thrombus, and angioplasty of the stenotic lesion. This report describes a phase I trial

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