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FCMAB314F

Sigma-Aldrich

Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B

clone 11-5B, Milli-Mark®, from mouse

Synonym(e):

2′3′-Cyclic Nucleotide 3′-Phosphohydrolase

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Konjugat:
FITC conjugate
application:
FACS
Klon:
11-5B, monoclonal
Speziesreaktivität:
human
citations:
Methode(n):
flow cytometry: suitable

Biologische Quelle

mouse

Qualitätsniveau

Konjugat

FITC conjugate

Antikörperform

purified antibody

Antikörper-Produkttyp

primary antibodies

Klon

11-5B, monoclonal

Speziesreaktivität

human

Hersteller/Markenname

Milli-Mark®

Methode(n)

flow cytometry: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CNP(1267)

Allgemeine Beschreibung

CNPase (2′, 3′-cyclic nucleotide 3′-phosphodiesterase [or -phosphohydrolase], EC 3.1.4.37) is present in very high levels in brain and peripheral nerve. This enzyme is found almost exclusively in oligo-dendrocytes and Schwann cells, the cells that form myelin in the central and peripheral nervous system, respectively.
Immunohistochemical localization of CNPase has shown the enzyme to be restricted to oligodendrocytes and Schwann cells. The enzyme appears to be distributed in single and double loose wraps of myelin and not in compact myelin as earlier thought by most investigators. CNPase is located on the inner and outer loops of myelin, paranodally and near the inner surface of the oligodendrocyte membrane. In plaque regions of multiple sclerosis patients, the enzyme is reduced, and when CNS myelin is decreased, CNPase is one of the earlier proteins to be lost from the myelin. In addition, an enzyme that is probably identical to brain CNPase is located in the outer rod segments within the visual system, and this protein is also recognized by the monoclonal antibody 11-5B. In mixed human gliomas, the enzyme levels are reduced, although about 5% of the oligodendrocytes occasionally show normal positive staining.

Spezifität

Antibody recognizes Human CNPase protein.

Immunogen

Purified human brain CNPase protein.

Anwendung

Research Category
Neurowissenschaft
Research Sub Category
Neuronen- & Gliamarker
Detect CNPase using this Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B validated for use in FC.

Qualität

Evaluated by flow cytometry using U251 Cells.

Zielbeschreibung

48kDa Calculated

Physikalische Form

Protein A purified
Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Lagerung und Haltbarkeit

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Hinweis zur Analyse

Control
U251 Cells

Rechtliche Hinweise

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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