ABC471

Anti-KLF15 Antibody

1.0 mg/mL, from rabbit

• Synonym(e): Krueppel-like factor 15, Kidney-enriched krueppel-like factor, KLF15
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: human
• Speziesreaktivität (Voraussage durch Homologie): primate (based on 100% sequence homology), bat (based on 100% sequence homology), baboon (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), monkey (based on 100% sequence homology)
• Konzentration: 1.0 mg/mL
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_054798
• UniProt-Hinterlegungsnummer: Q9UIH9
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... KLF15(28999)

Beschreibung

Allgemeine Beschreibung

KLF15, also known as Krueppel-like factor 15, Kidney-enriched krueppel-like factor, and encoded by the gene KLF15/KKLF, is a transcriptional regulator that affects expression in a wide variety of developmental and cellular systems. These include glial cell differentiation, cardiac circadian expression regulation, podocyte differentiation, glomerular visceral epithelial cell differentiation, glucose transport, and negative regulation of Peptidyl-lysine acetylation. KLF15 is highly expressed in liver, skeletal muscle, cardiomyocytes and kidney cells. KLF15 is a biomarker in patients with non-ischemic cardiomyopathy, glomerular disease, and aortic aneurysm. In such patients KLF15 expression is severely down regulated. KLF15 deficiency affects the cardiac rhythm and may play a role in ventricular arrhythmias and pathological conditions of the heart.

Immunogen

Epitope: Unknown

KLH-conjugated linear peptide corresponding to human KLF15.

Anwendung

Research Category
Apoptose & Krebs

Research Sub Category
Apoptose - Weiterführende Produkte

Anti-KLF15 Antibody detects level of KLF15 & has been published & validated for use in KLF15.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected KLF15 in human liver tissue.

Qualität

Evaluated by Western Blotting in human skeletal muscle tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected KLF15 in 10 µg of human skeletal muscle tissue lysate.

Zielbeschreibung

~46 kDa observed

Physikalische Form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable