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Merck

AB5559

Sigma-Aldrich

Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop

Chemicon®, from rabbit

Synonym(e):

Anti-CAE2, Anti-DEE74, Anti-ECA2, Anti-EIEE74, Anti-FEB8, Anti-GEFSP3

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Antikörperform

affinity purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

rat

Hersteller/Markenname

Chemicon®

Methode(n)

immunoprecipitation (IP): suitable
western blot: suitable

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... GABRG2(2566)

Spezifität

GABAA receptor gamma2 subunit. Reacts with the ~44-47kDa gamma2 subunit of the GABAA receptor in rat brain membrane fractions.

Immunogen

Epitope: cytoplasmic loop
MBP fusion protein from the cytosolic loop of rat GABAA receptor gamma2 subunit.

Anwendung

Research Category
Neurowissenschaft
Research Sub Category
Neurotransmitter & Rezeptoren
Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop detects level of GABA A Receptor γ2 & has been published & validated for use in IP & WB.
Western blot: 1:1,000

Immunopreciptation: The antibody will immunoprecipitate 49% of all GABAA receptors in dodecylsulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.

Optimal working dilutions must be determined by the end user.

Physikalische Form

Affinity purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. Approximate concentration is 0.2 mg/mL.

Lagerung und Haltbarkeit

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Yan Li et al.
Frontiers in aging neuroscience, 9, 212-212 (2017-07-18)
A decline in cardiovascular modulation is a feature of the normal aging process and associated with cardiovascular diseases (CVDs) such as hypertension and stroke. Exercise training is known to promote cardiovascular adaptation in young animals and positive effects on motor
Ciria C Hernandez et al.
Biomolecules, 13(3) (2023-03-30)
Febrile seizures (FS) are the most common form of epilepsy in children between six months and five years of age. FS is a self-limited type of fever-related seizure. However, complicated prolonged FS can lead to complex partial epilepsy. We found
Shimian Qu et al.
Brain communications, 2(1), fcaa028-fcaa028 (2020-05-30)
The Lennox-Gastaut syndrome is a devastating early-onset epileptic encephalopathy, associated with severe behavioural abnormalities. Its pathophysiology, however, is largely unknown. A de novo mutation (c.G358A, p.D120N) in the human GABA type-A receptor β3 subunit gene (GABRB3) has been identified in
Ciria C Hernandez et al.
Biomolecules, 13(12) (2023-12-23)
Variants in the GABRB gene, which encodes the β subunit of the GABAA receptor, have been implicated in various epileptic encephalopathies and related neurodevelopmental disorders such as Dravet syndrome and Angelman syndrome. These conditions are often associated with early-onset seizures
Adam J Harrington et al.
eLife, 5 (2016-11-04)
Numerous genetic variants associated with MEF2C are linked to autism, intellectual disability (ID) and schizophrenia (SCZ) - a heterogeneous collection of neurodevelopmental disorders with unclear pathophysiology. MEF2C is highly expressed in developing cortical excitatory neurons, but its role in their

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