OK to freeze desiccated (hygroscopic) protect from light
Lagertemp.
−70°C
Allgemeine Beschreibung
Inhibits the tyrosine kinase activity of FGFR1 (IC50 = 10-20 µM in the presence of 1 mM ATP) by interacting with the catalytic domain of FGFR1. Also inhibits aFGF-induced phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984, it acts only as a weak inhibitor of tyrosine phosphorylation of the PDGF receptor. Does not inhibit the phosphorylation of insulin receptor and exhibits no inhibitory effect on EGF receptor kinase.
Verpackung
Packaged under inert gas
Warnhinweis
Toxicity: Irritant (B)
Physikalische Form
A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572630) in DMSO.
Rekonstituierung
Following initial thaw, aliquot and freeze (-70°C).
Sonstige Hinweise
Mohammadi, M., et al. 1997. Science 276, 955.
Rechtliche Hinweise
Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Flammpunkt (°F)
188.6 °F - (refers to pure substance)
Flammpunkt (°C)
87 °C - (refers to pure substance)
Analysenzertifikate (COA)
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Development (Cambridge, England), 149(10) (2022-05-17)
The fibroblast growth factor (FGF) signalling pathway plays various roles during vertebrate embryogenesis, from mesoderm formation to brain patterning. This diversity of functions relies on the fact that vertebrates possess the largest FGF gene complement among metazoans. In the cephalochordate
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