5.05732

GBR 12909 Dihydrochloride

• Synonym(e): GBR 12909 Dihydrochloride, 1-(2-Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine Hydrochloride, Dopamine Active Transporter Inhibitor, GBR 12909, DAT Inhibitor, GBR 12909, GBR12909
• Empirische Formel (Hill-System): C₂₈H₃₂F₂N₂O · 2HCl
• CAS-Nummer: 67469-78-7
• Molekulargewicht: 523.49
• MDL-Nummer: MFCD00055193
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Wirksamkeit: 1 nM K_i
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white to off-white
• Löslichkeit: DMSO: 100 mM
• Lagertemp.: 2-8°C
• InChI: 1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
• InChIKey: MIBSKSYCRFWIRU-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A potent inhibitor of dopamine active transporter (DAT, K_i = 1 nM, IC₅₀ = 40 and 51 nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.

Biochem./physiol. Wirkung

Primary Target
DAT

Warnhinweis

Toxicity: Standard Handling (A)

Angaben zur Herstellung

Slight warming is required for complete solubilization.

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Young, J. et al. 2010. Psychopharm.208, 443.

Hewitt, K., et al. 2009. Neuropharm.57, 678.
Prisinzano, T. et al. 2002. J. Med. Chem.45, 4371.
Andersen, P., et al. 1989. Eur. J. Pharmacol.166, 493.
Heikkila, R., et al. 1984. Eur. J. Pharmacol.103, 142.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable