407625

STAT3 Inhibitor XVI

The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(e): STAT3 Inhibitor XVI, IL-6 Inhibitor
• Empirische Formel (Hill-System): C₂₁H₂₂N₂O₃S₃
• CAS-Nummer: 1260364-43-9
• Molekulargewicht: 446.61
• MDL-Nummer: MFCD32671868
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: gray
• Löslichkeit: DMSO: 50 mg/mL, light pink-purple
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• SMILES String: O=C(NCC1=CC=CS1)C2=CC(S(N3CCCC3)(=O)=O)=C(C4=CC=C(C)C=C4)S2

Beschreibung

Allgemeine Beschreibung

A cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC₅₀ = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 &micro:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Regulatory Review (Z)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Zinzalla, G., et al. 2010. Bioorg Med Chem Lett20, 7029.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable