219672

CFTR Inhibitor III, OXO-172

The CFTR Inhibitor III, OXO-172 controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Synonym(e): CFTR Inhibitor III, OXO-172, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172
• Empirische Formel (Hill-System): C₁₈H₁₀F₃NO₄S
• Molekulargewicht: 393.34
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC, NMR)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: off-white
• Löslichkeit: ethanol: 1 mg/mL; DMSO: 50 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

A cell-permeable CFTR_inh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTR_inh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTR_inh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC₅₀ = 1.4 µM vs. 0.38 µM with CFTR_inh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).

A cell-permeable CFTR_inh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTR_inh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTR_inh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC₅₀ = 1.4 µM vs. 0.38 µM with CFTR_inh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Irritant (B)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Sonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem.16, 8187.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable