138000

D-Amino Acid Oxidase Inhibitor

The D-Amino Acid Oxidase Inhibitor, also referenced under CAS 39793-31-2, controls the biological activity of D-Amino Acid Oxidase.

• Synonym(e): D-Amino Acid Oxidase Inhibitor, 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8
• Empirische Formel (Hill-System): C₇H₅NO₂S
• CAS-Nummer: 39793-31-2
• Molekulargewicht: 167.19
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: beige
• Löslichkeit: 5% NaOH: 25 mg/mL; DMSO: 80 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• InChI: 1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10)
• InChIKey: PMHDSACGRKBACK-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC₅₀ against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC₅₀ >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC₅₀ >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Harmful (C)

Rekonstituierung

Unstable in solution; reconstitute just prior to use.

Sonstige Hinweise

Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther.328, 921.
Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett.18, 3386.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable