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Merck
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05-672

Sigma-Aldrich

Anti-dimethyl-Histone H4 (Lys20) Antibody, clone 6G7/H4

clone 6G7/H4, Upstate®, from mouse

Synonym(e):

H4K20me2, Histone H4 (di methyl K20)

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörper-Produkttyp

primary antibodies

Klon

6G7/H4, monoclonal

Speziesreaktivität

human, bovine, mouse, rat

Hersteller/Markenname

Upstate®

Methode(n)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

NM_175054

UniProt-Hinterlegungsnummer

P62805

Versandbedingung

dry ice

Posttranslationale Modifikation Target

dimethylation (Lys20)

Angaben zum Gen

bovine ... H4C1(617905)
human ... H4C1(8359)
mouse ... H4C1(326619)

Spezifität

methyl-Histone H4

Immunogen

peptide corresponding to amino acids 17-28 of human histone H4 (RHRdimKVLRDNIQGC) dimethylated on lysine 20.

Anwendung

Research Category
Epigenetik & nukleäre Funktionen
Research Sub Category
Histone
Use Anti-dimethyl-Histone H4 (Lys20) Antibody, clone 6G7/H4 (mouse monoclonal antibody) validated in IP, WB, IHC to detect dimethyl-Histone H4 (Lys20) also known as H4K20me2, Histone H4 (di methyl K20).

Qualität

routinely evaluated by immunoblot on HeLa acid extracts

Zielbeschreibung

10kDa

Physikalische Form

Protein G Chromatography
Format: Purified
PBS

Lagerung und Haltbarkeit

2 years at -20°C

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Kenichi Nishioka et al.
Molecular cell, 9(6), 1201-1213 (2002-06-28)
We have purified a human histone H4 lysine 20 methyltransferase and cloned the encoding gene, PR/SET07. A mutation in Drosophila pr-set7 is lethal: second instar larval death coincides with the loss of H4 lysine 20 methylation, indicating a fundamental role
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.
Frederick A Mallette,Francesca Mattiroli,Gaofeng Cui,Leah C Young,Michael J Hendzel et al.
The Embo Journal null
Ai-Shun Guo et al.
Molecular medicine reports, 14(5), 4613-4621 (2016-10-26)
The present study aimed to investigate the differential expression and clinical significance of histone methyltransferase G9a, histone H3K9me2 and histone H3K9me1 in human brain glioma and adjacent tissue samples. It also aimed to observe the effect and mechanism of BIX‑01294, as

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