N-090

Nortriptylin-D₃ -hydrochlorid -Lösung

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Empirische Formel (Hill-System): C₁₉D₃H₁₈N · HCl
• CAS-Nummer: 136765-48-5
• Molekulargewicht: 302.86
• MDL-Nummer: MFCD00198172
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329818468
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material
• Form: liquid
• Leistungsmerkmale: (Snap-N-Spike^®)
• Verpackung: ampule of 1 mL
• Hersteller/Markenname: Cerilliant^®
• Konzentration: 1.0 mg/mL in methanol (as free base)
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): clinical testing
• Format: single component solution
• Lagertemp.: −20°C
• SMILES String: [2H]C([2H])([2H])NCCC=C1C2=C(C=CC=C2)CCC3=C1C=CC=C3.[H]Cl
• InChI: 1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H/i1D3;
• InChIKey: SHAYBENGXDALFF-NIIDSAIPSA-N

Beschreibung

Allgemeine Beschreibung

Nortriptylin ist ein trizyklisches Antidepressivum (TZA) der zweiten Generation, das unter Handelsnamen wie Sensoval, Aventyl^® und Pamelor^® zur Behandlung von schweren Depressionen vermarktet wird. Nortriptylin ist auch ein aktiver Metabolit des TZA Amitriptylin. Diese zertifizierte Snap-N-Spike^®-Lösung eignet sich als interner Standard zur Quantifizierung von Nortriptylin mittels LC/MS oder GC/MS in der klinischen Toxikologie, forensischen Analytik, Drogentests im Urin, Isotopenverdünnungsverfahren oder Arzneimittelüberwachungsanwendungen.

Anwendung

• Mass spectrometry standard: Nortriptyline-D3 hydrochloride solution is utilized as a high-precision internal standard in mass spectrometry to quantify nortriptyline levels in biological samples, essential for clinical pharmacokinetic studies and therapeutic drug monitoring.
• Metabolite research: As a stable isotope-labeled nortriptyline, it aids in metabolite profiling, helping researchers identify and quantify nortriptyline metabolites in various matrices, which is crucial for understanding drug metabolism and disposition.
• Pharmacokinetic studies: The solution is applied in pharmacokinetic research to assess the absorption, distribution, metabolism, and excretion (ADME) of nortriptyline, providing insights into the drug′s efficacy and safety profiles.
• Quantitative analysis: In bioanalytical research, Nortriptyline-D3 hydrochloride serves as a standard in developing and validating analytical methods, ensuring accuracy and reproducibility in the quantification of nortriptyline in pharmaceutical formulations and clinical samples.

Rechtliche Hinweise

Aventyl is a registered trademark of Eli Lilly and Co.

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Pamelor is a registered trademark of Mallinckrodt Inc.

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H225,H301 + H311 + H331,H370
• P-Sätze: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Zielorgane: Eyes
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 1
• Flammpunkt (°F): 49.5 °F
• Flammpunkt (°C): 9.7 °C