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870818M

Avanti

N-arachidonoylglycine

Avanti Research™ - A Croda Brand 870818M, methylene chloride solution

Synonym(e):

methylene chloride solution

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About This Item

Empirische Formel (Hill-System):
C22H35NO3
CAS-Nummer:
179113-91-8
Molekulargewicht:
361.52
UNSPSC-Code:
12352211
NACRES:
NA.25

Form

methylene chloride solution

Verpackung

pkg of 1 × 1 mL (870818M-10mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 870818M

Lipid-Typ

neutral glycerides
neutral lipids

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)NCC(O)=O

InChI

1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/b7-6-,10-9-,13-12-,16-15-

InChIKey

YLEARPUNMCCKMP-DOFZRALJSA-N

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Allgemeine Beschreibung

N-arachidonoylglycine (NAgly) is an endogenous ligand and a signaling lipid. It belongs to the eicosanoid family. NAgly is a natural ligand to activate G-protein coupled receptor, namely GPR18. It is found in rat brain and spinal cord.

Biochem./physiol. Wirkung

N-arachidonoylglycine (NAgly) exhibits analgesic effects.

Verpackung

2 mL Amber Glass Sealed Ampule (870818M-10mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Warning

Gefahreneinstufungen

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Central nervous system

WGK

WGK 2

Analysenzertifikate (COA)

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Resolution of inflammation by N-arachidonoylglycine
Burstein S H, et al.
Journal of Cellular Biochemistry, 112(11), 3227-3233 (2011)
S M Huang et al.
The Journal of biological chemistry, 276(46), 42639-42644 (2001-08-24)
In mammals, specific lipids and amino acids serve as crucial signaling molecules. In bacteria, conjugates of lipids and amino acids (referred to as lipoamino acids) have been identified and found to possess biological activity. Here, we report that mammals also
T Sheskin et al.
Journal of medicinal chemistry, 40(5), 659-667 (1997-02-28)
In order to establish the structural requirements for binding to the brain cannabinoid receptor (CB1), we have synthesized numerous fatty acid amides, ethanolamides, and some related simple derivatives and have determined their Ki values. A few alpha-methyl- or alpha, alpha-dimethylarachidonoylalkylamides
S H Burstein et al.
Prostaglandins & other lipid mediators, 61(1-2), 29-41 (2000-04-29)
In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2
Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18
Kohno M, et al.
Biochemical and Biophysical Research Communications, 347(3), 827-832 (2006)
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