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700072P

Avanti

zymosterol-d5

Avanti Research™ - A Croda Brand

Synonym(e):

(2,2,3,4,4-D5)-5α-cholesta-8,24-dien-3β-ol

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About This Item

Empirische Formel (Hill-System):
C27H39D5O
CAS-Nummer:
1246298-29-2
Molekulargewicht:
389.67
UNSPSC-Code:
12352211
NACRES:
NA.25

Beschreibung

(2,2,3,4,4-d5)-zymosterol

Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1 × 1 mg (700072P-1mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

C[C@]12CCC([C@](CC([2H])([2H])[C@@](O)([2H])C3([2H])[2H])(C)C3CC4)=C4[C@]1([H])CC[C@]2([H])[C@]([H])(C)CCC=C(C)C

Allgemeine Beschreibung

Zymosterol-d5 is the deuterated form of zymosterol. Zymosterol is a precursor of cholesterol and the synthesis events occur in rough endoplasmic reticulum.

Anwendung

Zymosterol-d5 has been used as a standard in liquid chromatography–mass spectrometry (LC-MS) for quantification of sterols from human plasma samples.

Biochem./physiol. Wirkung

Zymosterol is a substrate for 24-dehydrocholesterol reductase. It acts as a methyl acceptor and exists as fatty acid ester aerobically-grown yeast cells.

Verpackung

5 mL Amber Glass Screw Cap Vial (700072P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

No data available

Flammpunkt (°C)

No data available

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Jeffrey G McDonald et al.
Journal of lipid research, 53(7), 1399-1409 (2012-04-21)
We describe the development of a method for the extraction and analysis of 62 sterols, oxysterols, and secosteroids from human plasma using a combination of HPLC-MS and GC-MS. Deuterated standards are added to 200 μl of human plasma. Bulk lipids
N Ariga et al.
Journal of biochemistry, 83(4), 1109-1116 (1978-04-01)
In order to identify the methyl acceptor for the methylation of sterol side-chains in ergosterol biosynthesis, Saccharomyces cerevisiae (wild type) was grown in the presence and absence of ethionine which was expected to be an inhibitor of the methylation. Gas-liquid
Y Lange et al.
The Journal of biological chemistry, 266(32), 21439-21443 (1991-11-15)
Where examined, cholesterol is synthesized in the endoplasmic reticulum; however, its precursor, zymosterol, is found mostly in the plasma membrane. The novel implication of these disparate findings is that zymosterol circulates within the cell. In tracing its movements, we have
Natalia Mast et al.
PloS one, 12(10), e0187168-e0187168 (2017-10-27)
Cytochrome P450 46A1 (CYP46A1) converts cholesterol to 24-hydroxycholesterol and thereby controls the major pathways of cholesterol removal from the brain. Cyp46a1-/- mice have a reduction in the rate of cholesterol biosynthesis in the brain and significant impairments to memory and

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